The protective effect of melatonin in lungs of newborn rats exposed to maternal nicotine

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dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authoridYildiz, Azibe/0000-0001-5686-7867
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.authorwosidYildiz, Azibe/ABI-7998-2020
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.contributor.authorYildiz, A.
dc.contributor.authorVardi, N.
dc.contributor.authorKaraaslan, M. G.
dc.contributor.authorAtes, B.
dc.contributor.authorTaslidere, E.
dc.contributor.authorEsrefoglu, M.
dc.date.accessioned2024-08-04T20:44:26Z
dc.date.available2024-08-04T20:44:26Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe investigated possible healing effects of melatonin (MEL) on biochemical and histological changes in the lungs of rat offspring caused by exposure to nicotine (NT) in utero. Pregnant rats were divided randomly into five groups. The SP group was treated with physiological saline. The EA group was treated with ethyl alcohol. The MEL group was treated with MEL. The NT group was treated with NT. The NT + MEL group was treated with NT and MEL. At the end of the study, the biochemistry and histopathology of lung tissue of the offspring were examined. Reduced alveolar development and increased numbers of alveolar macrophages and mast cells were observed in the NT group compared to the SP, EA and MEL groups. We also found increased malondialdehyde (MDA) levels and decreased total glutathione (GSH) levels in the NT group. Application of MEL ameliorated the histological and biochemical damage caused by NT. The number of alveoli was greater in the NT + MEL group than in the NT group. Also, the increased numbers of alveolar macrophages and mast cells resulting from exposure to NT were decreased following MEL treatment. We found that MEL caused a significant decrease in the level of MDA. Maternal exposure to NT caused significant structural and biochemical changes in the lungs of the offspring and administration of MEL ameliorated the changes.en_US
dc.identifier.doi10.1080/10520295.2018.1453548
dc.identifier.endpage452en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue6en_US
dc.identifier.pmid29701082en_US
dc.identifier.scopus2-s2.0-85046025398en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage442en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2018.1453548
dc.identifier.urihttps://hdl.handle.net/11616/98254
dc.identifier.volume93en_US
dc.identifier.wosWOS:000447625300006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthistopathologyen_US
dc.subjectlungen_US
dc.subjectmaternalen_US
dc.subjectmelatoninen_US
dc.subjectnicotineen_US
dc.subjectoxidative stressen_US
dc.subjectratsen_US
dc.titleThe protective effect of melatonin in lungs of newborn rats exposed to maternal nicotineen_US
dc.typeArticleen_US

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