Effects of injectable platelet-rich fibrin in experimental periodontitis in rats

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dc.authoridSancak, Tunahan/0000-0002-7813-1575
dc.authoridTaskin, Cem/0000-0002-7852-4010
dc.authoridSahin Aydinyurt, Hacer/0000-0002-9521-9704
dc.authorwosidSancak, Tunahan/N-2802-2018
dc.authorwosidAKINCI, Levent/W-3128-2017
dc.contributor.authorAydinyurt, Hacer Sahin
dc.contributor.authorSancak, Tunahan
dc.contributor.authorTaskin, Cem
dc.contributor.authorBasbugan, Yildiray
dc.contributor.authorAkinci, Levent
dc.date.accessioned2024-08-04T20:49:00Z
dc.date.available2024-08-04T20:49:00Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractInjectable platelet-rich fibrin (i-PRF) is an effective biological material that positively contributes to angiogenesis, wound healing, inflammation, regeneration processes, etc. This research aimed to evaluate the effect of i-PRF in rats with experimental periodontitis. Following the development of ligature-induced periodontitis, 24 Wistar albino rats were divided into three groups. Group-1: scaling and root planing (only-SRP); Group-2: SRP + i-PRF; Group-3: only- i-PRF. Heart blood from six donors was used for the i-PRF application. i-PRF was administered as a subgingival injection in the relevant groups on the 1st, 3rd, and 7th days. The tissues were evaluated histopathologically and immunohistochemically. Also, bone structures were examined using micro-CT. According to the data obtained, no statistically significant difference was observed among the groups in terms of bone resorption, inflammation, bone volume, bone levels (mesial/distal), and IL-1 beta, IFN-r, TNF-alpha, VEGF values (p > 0.05). However, bone mineral density was statistically significantly different among the groups (Group3 > Group2 > Group1) (p < 0.0001). Subgingival injection of only-i-PRF showed promising results in periodontitis treatment but contribution to SRP has not been proved according to this study results. The study results suggested that the i-PRF application was as effective as SRP in reducing bone loss, modulating inflammatory process, and effecting cytokines in experimental periodontitis. The significant effect of i-PRF on bone mineral density was the most remarkable result.en_US
dc.description.sponsorshipVan Yuzuncu Yil University Scientific Research Projects Coordination Unit [TSA-2018-7436]en_US
dc.description.sponsorshipThis research was supported by Van Yuzuncu Yil University Scientific Research Projects Coordination Unit (Project Code: TSA-2018-7436).en_US
dc.identifier.doi10.1007/s10266-020-00557-1
dc.identifier.endpage432en_US
dc.identifier.issn1618-1247
dc.identifier.issn1618-1255
dc.identifier.issue2en_US
dc.identifier.pmid33068206en_US
dc.identifier.scopus2-s2.0-85092676979en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage422en_US
dc.identifier.urihttps://doi.org/10.1007/s10266-020-00557-1
dc.identifier.urihttps://hdl.handle.net/11616/99588
dc.identifier.volume109en_US
dc.identifier.wosWOS:000579063600002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofOdontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPeriodontitisen_US
dc.subjectPlatelet-rich fibrinen_US
dc.subjectAnimal experimentationen_US
dc.subjectInterleukin-1betaen_US
dc.subjectVEGFen_US
dc.subjectTumor necrosis factor-alphaen_US
dc.titleEffects of injectable platelet-rich fibrin in experimental periodontitis in ratsen_US
dc.typeArticleen_US

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