Comparative amelioration of renal histomorphology by ascorbic acid and Camellia sinensis extract in Wistar rats exposed to Lead-induced nephropathy
| dc.contributor.author | Omotoso, Dayo Rotimi | |
| dc.contributor.author | Owonikoko, Wasiu Mathew | |
| dc.contributor.author | Ehiemere, Winners Prince | |
| dc.date.accessioned | 2022-03-14T06:07:07Z | |
| dc.date.available | 2022-03-14T06:07:07Z | |
| dc.date.issued | 2020 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Aim: To compare the ameliorative effects of ascorbic acid and Camellia sinensis extract on renal histomorphology of lead-induced nephropathic rats. Material and methods: Twenty four rats were randomly grouped into four groups (I–IV) as follows: Normal control group I administered distilled water (5 ml/kg), Test control group II administered lead acetate (2 mg/ml), Treated group III administered lead acetate (2 mg/ml) + ascorbic acid (100 mg/kg), Treated group IV administered lead acetate (2 mg/ml) + Camellia sinensis extract (10 mg/kg). All administrations were done through oral route and lasted for 30 days. Results: Body and renal tissue weight of study animals were significantly reduced (p 0.05) in test control relative to normal control while treated groups showed non-significant reduction. Histological examination of renal tissue showed significant prominence of histopathological features such as inflammation, necrosis and glomerular congestion in test control group while treated groups showed marked reduction.Conclusion: According to the findings of this study, treatment with ascorbic acid or Camellia sinensis extract comparatively exert ameliorative effects on lead-induced nephropathy in Wistar rats which in turn culminates into reparative influence on their renal histomorphology. | en_US |
| dc.identifier.citation | Rotimi Omotoso, D., Mathew Owonikoko, W., & Prince Ehiemere, W. (2021). Comparative amelioration of renal histomorphology by ascorbic acid and Camellia sinensis extract in Wistar rats exposed to Lead-induced nephropathy . Annals of Medical Research | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/55120 | |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Annals of Medical Research | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Comparative amelioration of renal histomorphology by ascorbic acid and Camellia sinensis extract in Wistar rats exposed to Lead-induced nephropathy | en_US |
| dc.type | Article | en_US |
