Deceased donor liver transplantation from donors with central nervous system malignancy: Experience of the Inonu University

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dc.authoridince, volkan/0000-0002-0714-490X
dc.authoridErsan, Veysel/0000-0002-1510-0288
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridÖZDEMİR, FATİH/0000-0003-0292-3602
dc.authoridOzdemir, Fatih/0000-0003-0292-3602
dc.authoridIsik, Burak/0000-0002-2395-3985
dc.authoridKoc, Cemalettin/0000-0002-5676-6772
dc.authorwosidince, volkan/M-7325-2017
dc.authorwosidErsan, Veysel/AAB-9595-2020
dc.authorwosidKayaalp, Cuneyt/AAH-1764-2021
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidÖZDEMİR, FATİH/HJI-7585-2023
dc.authorwosidOzdemir, Fatih/ABH-2875-2020
dc.authorwosidBarut, Bora/ABD-9882-2020
dc.contributor.authorInce, Volkan
dc.contributor.authorErsan, Veysel
dc.contributor.authorOzdemir, Fatih
dc.contributor.authorBarut, Bora
dc.contributor.authorKoc, Cemalettin
dc.contributor.authorIsik, Burak
dc.contributor.authorKayaalp, Cuneyt
dc.date.accessioned2024-08-04T20:10:30Z
dc.date.available2024-08-04T20:10:30Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: Liver transplantation from deceased donors with a central nervous system (CNS) malignancy has some risk of tumor transmission to the recipient. Though the risk is small, this group of donors is regarded as marginal. The use of marginal grafts may be an acceptable alternative practice in order to expand the donor pool in countries where there is a shortage of donated organs. The aim of this study was to examine and present the outcomes of liver transplantations performed using donors with a CNS tumor. METHODS: Between March 2002 and July 2017, 1990 (deceased donor: n=399, 20%; living donor: n=1591, 80%) liver transplantations were performed at the center. Of the 399 deceased donors, 17 (4.2%) had a CNS tumor. The data of donors with a CNS tumor and of recipients who survived for more than 1 month (n=11) were retrospectively reviewed. Demographic data, the grade of the CNS tumor, tumor transmission to recipient data, and survival rates were analyzed. RESULTS: Only 2 (18%) grafts were provided locally, 6 (54%) were offered to the transplantation center after all of the national centers had declined them, and 3 (37%) were made available to us by the national coordination center for patients with a documented notification of urgency. High-grade (grade III-IV) brain tumors were detected in 7 (64%) donors, while low-grade (grade I-II) tumors were found in 2 patients. The remaining 2 donors were not pathologically graded because the diagnosis was made radiologically. The 1-, 3-, and 5-year overall and tumor-free survival of the patients was estimated at 100%, 70%, and 45%, respectively. CONCLUSION: A median survival of 40 months (range: 13-62 months) was achieved in recipients of grafts from a donor with a CNS tumor and no donor-related malignant transformation was observed.en_US
dc.identifier.doi10.14744/nci.2017.74436
dc.identifier.endpage217en_US
dc.identifier.issn2148-4902
dc.identifier.issn2536-4553
dc.identifier.issue3en_US
dc.identifier.pmid29270568en_US
dc.identifier.startpage213en_US
dc.identifier.trdizinid252195en_US
dc.identifier.urihttps://doi.org/10.14744/nci.2017.74436
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/252195
dc.identifier.urihttps://hdl.handle.net/11616/92801
dc.identifier.volume4en_US
dc.identifier.wosWOS:000419173500002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofNorthern Clinics of Istanbulen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCentral nervous system tumoren_US
dc.subjectdecreaseden_US
dc.subjectliver transplantationen_US
dc.titleDeceased donor liver transplantation from donors with central nervous system malignancy: Experience of the Inonu Universityen_US
dc.typeArticleen_US

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