Intracerebroventricular salusin-? infusion to rats increases hypothalamus-pituitary-testicular axis hormones

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dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidVardı, Nigar/C-9549-2018
dc.contributor.authorDemir, Ilker
dc.contributor.authorTekin, Suat
dc.contributor.authorVardi, Nigar
dc.contributor.authorSandal, Suleyman
dc.date.accessioned2024-08-04T20:50:18Z
dc.date.available2024-08-04T20:50:18Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSalusin-beta (Sal-beta), which originates from preprosalusin, is a multifunctional hormone with a peptide structure. Sal-beta exists in the hypothalamus and can stimulate the pituitary gland. The present study was conducted to determine the effects of Sal-beta on hormones that play roles in the male reproductive system. Forty male Wistar Albino rats were used in the study. No infusions were performed on the control group, and infusions were applied to the infusion groups (artificial cerebrospinal fluid to the sham group, 2 and 20 nM Sal-beta to the experimental group) through intracerebroventricular infusion for 7 days at 10 mu l/hour rate. The animals were decapitated after 7 days of infusion; and the hypothalamus, testicles, and blood tissue samples were collected. The gonadotropin-releasing hormone (GnRH) mRNA levels were determined from the hypothalamus tissues by using the Real Time-PCR Method, and the serum luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone levels were determined using the ELISA method. Also, Hematoxylin-Eosin Staining Method was used for histopathological evaluations in the testicle tissues. As a result, Sal-beta infusion increased GnRH mRNA levels in hypothalamus tissues (p < 0.05) besides, serum LH, FSH, and testosterone levels of the rats were higher at significant levels following Sal-beta infusion compared to the control and sham group (p < 0.05). In the histological examination of the testicle tissues, Sal-beta application was found to decrease the seminiferous tubule diameter and germinal epithelial thickness (p < 0.05). This evidence is the first, indicating that Sal-beta, which is administered to male rats with central infusion, stimulates hypothalamus and pituitary tissues, and causes increased secretion of male reproductive hormones.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Unit [TSG-2017-952]en_US
dc.description.sponsorshipThis work was supported by the Inonu University Scientific Research Projects Unit (Project no: TSG-2017-952).en_US
dc.identifier.doi10.1016/j.ygcen.2021.113820
dc.identifier.issn0016-6480
dc.identifier.issn1095-6840
dc.identifier.pmid34015344en_US
dc.identifier.scopus2-s2.0-85107686555en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.ygcen.2021.113820
dc.identifier.urihttps://hdl.handle.net/11616/99981
dc.identifier.volume310en_US
dc.identifier.wosWOS:000672509400013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofGeneral and Comparative Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSalusin-betaen_US
dc.subjectTesticleen_US
dc.subjectGnRHen_US
dc.subjectLHen_US
dc.subjectFSHen_US
dc.subjectTestosteroneen_US
dc.titleIntracerebroventricular salusin-? infusion to rats increases hypothalamus-pituitary-testicular axis hormonesen_US
dc.typeArticleen_US

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