Synthesis of some new pyridylethylated benzoxa [Thia]zolinones with analgesic activity
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Tarih
2004
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info:eu-repo/semantics/openAccess
Özet
Synthesis of some new pyridylethylated benzoxa [Thia]zolinones with analgesic activity
Abstract: Eighteen new 3-[2-(2-/4-pyridyl)ethyl]benzoxazolinone(benzothiazolinone) derivatives were synthesized by reacting 2-/4-vinylpyrJdine and appropriate benzoxazolinones and benzothiazolinones. The analgesic activities of these compounds were investigated by modified Koster and hot-plate tests. Test results revealed that most of the compounds at 100 mg/kg dose levels have higher analgesic activities than acetylsalicylic acid. Compounds with bromo substituents on the phenyl ring in the 6-position of the main ring seemed to show less activity than those with fluorinated ones. Compound 6b showed remarkably high activity in the hot-plate test, although it was inactive in the Koster test. However compound 3a had statistically significant high peripheral analgesic activity at all doses compared to other compounds, although it was inactive in the hot-plate test.
Abstract: Eighteen new 3-[2-(2-/4-pyridyl)ethyl]benzoxazolinone(benzothiazolinone) derivatives were synthesized by reacting 2-/4-vinylpyrJdine and appropriate benzoxazolinones and benzothiazolinones. The analgesic activities of these compounds were investigated by modified Koster and hot-plate tests. Test results revealed that most of the compounds at 100 mg/kg dose levels have higher analgesic activities than acetylsalicylic acid. Compounds with bromo substituents on the phenyl ring in the 6-position of the main ring seemed to show less activity than those with fluorinated ones. Compound 6b showed remarkably high activity in the hot-plate test, although it was inactive in the Koster test. However compound 3a had statistically significant high peripheral analgesic activity at all doses compared to other compounds, although it was inactive in the hot-plate test.
Açıklama
Anahtar Kelimeler
Kaynak
Turkish Journal of Chemistry
WoS Q Değeri
Scopus Q Değeri
Cilt
28
Sayı
1
Künye
KELEKÇİ N. G,AKTAY G,ERDOĞAN H (2004). Synthesis of some new pyridylethylated benzoxa [Thia]zolinones with analgesic activity. Turkish Journal of Chemistry, 28(1), 123 - 132.
