Investigation of the effect of gestational diabetes on fetal cardiac tissue in streptozotocin induced in rats(1)
Yükleniyor...
Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ACTA CIRURGICA BRASILEIRA, ALAMEDA RIO CLARO, 179-41, SAO PAULO, SP 01332-010, BRAZIL
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: To Investigate the cause of congenital anomalies resulted from gestational diabetes on fetal cardiac tissue in experimental animal study model.
Methods: Totally 12 female WIstar albino rats were divided Into two groups, each consisting of 6 rats. Streptozotocln (60 mg/kg) was administered intraperltoneally to the study group by dissolving In citrate solution. The rats with a blood glucose level of 200 mg/dL and above were considered to be diabetic rats. Total antioxidant status (TAS), total oxidative stress (TOS) and oxidative stress Index (OSI) values were calculated In the cardiac tissues and maternal serum samples of the fetuses delivered by cesarean section after the mating process. The cardiac tissues were also subjected to hlstopathologlcal examination.
Results: TOS and OSI values In fetal cardiac tissues of the diabetic rats were found to be significantly higher than that of the control group (p=0.026 and p=0.005). Histopathological examination revealed that the mitotic Index was lower and the cell organization was found to be damaged In the fetuses of the study group rats.
Conclusion: Increased levels of free oxygen radicals considered to be due to hyperglycemia may cause congenital anomalies, especially during organogenesis period, by disrupting cell homeostasis and adversely affecting mitosis.
Açıklama
Anahtar Kelimeler
Oxıdatıve Stress, Serum-Levels, Medıators
Kaynak
Acta cırurgıca brasıleıra
WoS Q Değeri
Scopus Q Değeri
Cilt
33
Sayı
4
Künye
Yılmaz, E. Gül, M. Melekoğlu, R. Türköz, Y. Özyalın, F. Parlakpınar, H. (2018). Cilt:33 Sayı:4, 306-313 ss.
