Comparison of growth factor concentrations in platelet-rich fibrin biomaterial in different systemic diseases

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dc.contributor.authorKuybu, Ismail
dc.contributor.authorAlan, Hilal
dc.contributor.authorSimsek, Mehmet Sait
dc.date.accessioned2026-04-04T13:37:31Z
dc.date.available2026-04-04T13:37:31Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractObjectiveThis study aimed to evaluate and compare the concentrations of Platelet-Derived Growth Factor (PDGF), Vascular Endothelial Growth Factor (VEGF), and Transforming Growth Factor (TGF) in platelet-rich fibrin (PRF) biomaterials obtained from individuals with various systemic diseases.Materials and MethodsA total of 65 individuals were included and divided into five groups: healthy controls (n = 13), patients diagnosed with diabetes (n = 13), patients receiving bisphosphonate therapy (n = 13), patients using immunomodulatory drugs (n = 13), and patients diagnosed with hepatitis (n = 13). PRF samples were collected from each participant and analyzed in a biochemistry laboratory using ELISA kits specific to PDGF, VEGF, and TGF. The growth factor concentrations were statistically compared across the groups.ResultsThe highest mean concentration of PDGF was observed in the hepatitis group. The highest mean concentrations of VEGF and TGF were found in patients using immunomodulatory drugs. However, the differences in growth factor concentrations among the groups were not statistically significant.ConclusionPRF is an effective biomaterial widely used in dentistry due to its rich content of growth factors. While no statistically significant differences were found in growth factor concentrations among individuals with different systemic conditions, a notable increase in these levels was observed in certain disease groups. These findings suggest that systemic diseases may influence the biological composition of PRF, warranting further investigation.
dc.description.sponsorshipScientific Research Projects Unit of Idot;nn University [1814]
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Unit of & Idot;nonu University (Project number: 1814).
dc.identifier.doi10.1007/s00784-025-06673-y
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.issue12
dc.identifier.orcid0009-0003-4177-140X
dc.identifier.pmid41313360
dc.identifier.scopus2-s2.0-105023334741
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s00784-025-06673-y
dc.identifier.urihttps://hdl.handle.net/11616/109881
dc.identifier.volume29
dc.identifier.wosWOS:001627723800002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofClinical Oral Investigations
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectPlatelet-rich fibrin
dc.subjectGrowth factors
dc.subjectSystemic diseases
dc.subjectEnzyme-linked immunosorbent assay
dc.subjectBiomarkers
dc.titleComparison of growth factor concentrations in platelet-rich fibrin biomaterial in different systemic diseases
dc.typeArticle

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