Angiotensin-converting enzyme gene polymorphism and risk of insulin resistance in PCOS

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dc.authoridYesilada, Elif/0000-0002-3743-5767
dc.authoridSahin, Ibrahim/0000-0002-6231-0034
dc.authorwosidYesilada, Elif/ABG-9600-2020
dc.authorwosidŞahin, İbrahim/HHY-8303-2022
dc.authorwosidÖZEROL, ELİF/AAA-6707-2021
dc.authorwosidSahin, Ibrahim/ABI-6050-2020
dc.contributor.authorCelik, Onder
dc.contributor.authorYesilada, Elif
dc.contributor.authorHascalik, Seyma
dc.contributor.authorCelik, Nilufer
dc.contributor.authorSahin, Ibrahim
dc.contributor.authorKeskin, Lezzan
dc.contributor.authorOzerol, Elif
dc.date.accessioned2024-08-04T20:32:22Z
dc.date.available2024-08-04T20:32:22Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to establish the frequency of angiotensin-converting enzyme (ACE) insertion (I) or deletion (D) gene polymorphism in women with polycystic ovary syndrome (PCOS) and to examine the association of this polymorphism with insulin resistance. A total of 32 women with PCOS and 31 healthy, age- and body mass index-matched controls were studied. Serum lipids, fasting glucose, insulin and other hormones concentrations were measured. Homeostasis model assessment was used to estimate insulin resistance (HOMA-IR). DNA was extracted from peripheral blood leukocytes and genotyping of ACE I/D polymorphism was carried out by polymerase chain reaction. ACE genotypes were distributed as follows: DD was present in 16 (50%), ID in 12 (37.5%) and II in four (12.5%) PCOS patients, and DD in seven (22.6%), ID in 20 (64.5%) and II in four (12.9%) of healthy subjects. The frequency of D and I alleles were found in 69% and 31% of the PCOS group and 55% and 45% in the control group, respectively. There were no significant differences regarding the genotypic distribution and allelic frequency between the groups. However the ACE DD genotype was significantly associated with serum insulin concentrations and HOMA-IR measurement (both P = 0.005). ACE DD genotype is associated with an increased insulin resistance in women with PCOS. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.rbmo.2009.12.014
dc.identifier.endpage498en_US
dc.identifier.issn1472-6483
dc.identifier.issn1472-6491
dc.identifier.issue4en_US
dc.identifier.pmid20138007en_US
dc.identifier.scopus2-s2.0-77951653085en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage492en_US
dc.identifier.urihttps://doi.org/10.1016/j.rbmo.2009.12.014
dc.identifier.urihttps://hdl.handle.net/11616/95025
dc.identifier.volume20en_US
dc.identifier.wosWOS:000276864900008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofReproductive Biomedicine Onlineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectangiotensin-converting enzyme geneen_US
dc.subjectinsulin resistanceen_US
dc.subjectPCOSen_US
dc.subjectpolymorphismen_US
dc.titleAngiotensin-converting enzyme gene polymorphism and risk of insulin resistance in PCOSen_US
dc.typeArticleen_US

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