Glial Cell Line-Derived Neurotrophic Factor, S-100 Protein and Synaptophysin Expression in Biliary Atresia Gallbladder Tissue

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dc.authoridDemircan, Mehmet/0000-0002-4022-1276
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridGÜRÜNLÜOĞLU, Kubilay/0000-0002-8315-1765
dc.authoridGURUNLUOGLU, SEMRA/0000-0002-9737-859X
dc.authoridTasci, Aytac/0000-0002-4024-5219
dc.authoridyildiz, turan/0000-0001-5317-7537
dc.authoridGul, Semir/0000-0002-4668-9603
dc.authorwosidceran ozcan, canan/HJZ-4187-2023
dc.authorwosidDemircan, Mehmet/B-1904-2008
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidceran özcan, canan ceran/B-1867-2018
dc.authorwosidGÜRÜNLÜOĞLU, Kubilay/AAO-5631-2020
dc.contributor.authorGurunluoglu, Semra
dc.contributor.authorCeran, Canan
dc.contributor.authorGurunluoglu, Kubilay
dc.contributor.authorKocbiyik, Alper
dc.contributor.authorGul, Mehmet
dc.contributor.authorYildiz, Turan
dc.contributor.authorBag, Harika Gozukara
dc.date.accessioned2024-08-04T20:49:24Z
dc.date.available2024-08-04T20:49:24Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: Biliary atresia (BA) is a disease that manifests as jaundice after birth and leads to progressive destruction of the ductal system in the liver. The aim of this study was to investigate histopathological changes and immunohistochemically examine the expression of glial cell line-derived neurotrophic factor (GDNF), synaptophysin, and S-100 protein in the gallbladder of BA patients. Methods: The study included a BA group of 29 patients and a control group of 41 children with cholecystectomy. Gallbladder tissue removed during surgery was obtained and examined immunohistochemically and histopathologically. Tissue samples of both groups were immunohistochemically assessed in terms of GDNF, S-100 protein, and synaptophysin expression. Expression was classified as present or absent. Inflammatory activity assessment with hematoxylin and eosin staining and fibrosis assessment with Masson's trichrome staining were performed for tissue sample sections of both groups. Results: Ganglion cells were not present in gallbladder tissue samples of the BA group. Immunohistochemically, GDNF, synaptophysin, and S-100 expression was not detected in the BA group. Histopathological examination revealed more frequent fibrosis and slightly higher inflammatory activity in the BA than in the control group. Conclusion: We speculate that GDNF expression will no longer continue in this region, when the damage caused by inflammation of the extrahepatic bile ducts reaches a critical threshold. The study's findings may represent a missing link in the chain of events forming the etiology of BA and may be helpful in its diagnosis.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Coordination Unit [TSA-2018-1303]en_US
dc.description.sponsorshipWe would like to thank Inonu University Scientific Research Projects Coordination Unit, which financed this research with the project code TSA-2018-1303.en_US
dc.identifier.doi10.5223/pghn.2021.24.2.173
dc.identifier.endpage186en_US
dc.identifier.issn2234-8646
dc.identifier.issn2234-8840
dc.identifier.issue2en_US
dc.identifier.pmid33833973en_US
dc.identifier.scopus2-s2.0-85102812229en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage173en_US
dc.identifier.urihttps://doi.org/10.5223/pghn.2021.24.2.173
dc.identifier.urihttps://hdl.handle.net/11616/99836
dc.identifier.volume24en_US
dc.identifier.wosWOS:000628789800007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Soc Pediatric Gastroenterology & Nutritionen_US
dc.relation.ispartofPediatric Gastroenterology Hepatology & Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiliary atresiaen_US
dc.subjectGlial cell line-derived neurotrophic factoren_US
dc.subjectSynaptophysinen_US
dc.subjectS-100 proteinen_US
dc.subjectGallbladderen_US
dc.titleGlial Cell Line-Derived Neurotrophic Factor, S-100 Protein and Synaptophysin Expression in Biliary Atresia Gallbladder Tissueen_US
dc.typeArticleen_US

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