Genotoxic and genoprotective effects of some antipsychotic drugs, methylphenidate and atomoxetine on human lymphocytes and HepG2 cells

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dc.authorscopusid57530724700
dc.authorscopusid12797912000
dc.authorscopusid57063226300
dc.contributor.authorSezer S.K.
dc.contributor.authorYuksel S.
dc.contributor.authorUcuz I.
dc.date.accessioned2024-08-04T20:00:48Z
dc.date.available2024-08-04T20:00:48Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: Aripiprazole, risperidone, atomoxetine, and methylphenidate are drugs commonly prescribed for many psychiatric conditions and can be used alone or in combination in children and adolescents. This study aimed to investigate comparatively the possible genotoxic effects or genoprotective potentials of these drugs on human lymphocytes and HepG2 cells. MATERIALS AND METHODS: Cytotoxicity analysis was performed with the cell viability test on human lymphocytes and HepG2 cells, and half-maximal inhibitory concentration (IC50) values of the drugs were determined, and three different doses (IC50, IC50, and IC50) were applied for genetic analysis. For the determined doses, cells with and without DNA damage were examined by comet analysis. RESULTS: In lymphocytes, aripiprazole and risperidone increased DNA damage at moderate and maximum doses, whereas atomoxetine increased DNA damage only at the maximum dose. In HepG2 cells, risperidone reduced DNA damage at all doses, while atomoxetine increased DNA damage at all doses. On the other hand, in the DNA-damaged cells induced by hydrogen peroxide (H2O2), DNA damage decreased at all concentrations of all drugs in both lymphocytes and HepG2 cells. CONCLUSIONS: As a result, the genotoxicity of the drugs was found to be dose-dependent, and all drugs showed a genoprotective effect on DNA-damaged cells. © 2024 Verduci Editore s.r.l. All rights reserved.en_US
dc.identifier.doi10.26355/eurrev_202402_35456
dc.identifier.endpage1365en_US
dc.identifier.issn1128-3602
dc.identifier.issue4en_US
dc.identifier.pmid38436168en_US
dc.identifier.scopus2-s2.0-85186953444en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1356en_US
dc.identifier.urihttps://doi.org/10.26355/eurrev_202402_35456
dc.identifier.urihttps://hdl.handle.net/11616/91021
dc.identifier.volume28en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Editore s.r.len_US
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAripiprazoleen_US
dc.subjectAtomoxetineen_US
dc.subjectCometen_US
dc.subjectCytotoxicityen_US
dc.subjectMethylphenidateen_US
dc.subjectRisperidone.en_US
dc.titleGenotoxic and genoprotective effects of some antipsychotic drugs, methylphenidate and atomoxetine on human lymphocytes and HepG2 cellsen_US
dc.typeArticleen_US

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