Molsidomine decreases hyperoxia-induced lung injury in neonatal rats

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dc.authoridDeveci, Mehmet Fatih/0000-0002-3328-4156
dc.authoridturgut, hatice/0000-0002-0490-7852
dc.authoridTANBEK, Kevser/0000-0003-2099-2273
dc.authoridTanbek, Kevser/0000-0003-2099-2273
dc.authoridAslan, Mehmet/0000-0001-5710-6592;
dc.authorwosidDeveci, Mehmet Fatih/IYS-3534-2023
dc.authorwosidturgut, hatice/IZQ-4154-2023
dc.authorwosidTANBEK, Kevser/ITR-9264-2023
dc.authorwosidTanbek, Kevser/ABI-1174-2020
dc.authorwosidAslan, Mehmet/AEL-7823-2022
dc.authorwosidKaya, Hüseyin/AAW-6805-2021
dc.contributor.authorAslan, Mehmet
dc.contributor.authorGokce, Ismail Kursat
dc.contributor.authorTurgut, Hatice
dc.contributor.authorTekin, Suat
dc.contributor.authorTaslidere, Asli Cetin
dc.contributor.authorDeveci, Mehmet Fatih
dc.contributor.authorKaya, Huseyin
dc.date.accessioned2024-08-04T20:53:42Z
dc.date.available2024-08-04T20:53:42Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackgroundThe study's objective is to evaluate if Molsidomine (MOL), an anti-oxidant, anti-inflammatory, and anti-apoptotic drug, is effective in treating hyperoxic lung injury (HLI).MethodsThe study consisted of four groups of neonatal rats characterized as the Control, Control+MOL, HLI, HLI + MOL groups. Near the end of the study, the lung tissue of the rats were evaluated with respect to apoptosis, histopathological damage, anti-oxidant and oxidant capacity as well as degree of inflammation.ResultsCompared to the HLI group, malondialdehyde and total oxidant status levels in lung tissue were notably reduced in the HLI + MOL group. Furthermore, mean superoxide dismutase, glutathione peroxidase, and glutathione activities/levels in lung tissue were significantly higher in the HLI + MOL group as compared to the HLI group. Tumor necrosis factor-alpha and interleukin-1 beta elevations associated with hyperoxia were significantly reduced following MOL treatment. Median histopathological damage and mean alveolar macrophage numbers were found to be higher in the HLI and HLI + MOL groups when compared to the Control and Control+MOL groups. Both values were increased in the HLI group when compared to the HLI + MOL group.ConclusionsOur research is the first to demonstrate that bronchopulmonary dysplasia may be prevented through the protective characteristics of MOL, an anti-inflammatory, anti-oxidant, and anti-apoptotic drug.ImpactMolsidomine prophylaxis significantly decreased the level of oxidative stress markers.Molsidomine administration restored the activities of antioxidant enzymes.Molsidomine prophylaxis significantly reduced the levels of inflammatory cytokines.Molsidomine may provide a new and promising therapy for BPD in the future.Molsidomine prophylaxis decreased lung damage and macrophage infiltration in the tissue.en_US
dc.identifier.doi10.1038/s41390-023-02643-w
dc.identifier.endpage1348en_US
dc.identifier.issn0031-3998
dc.identifier.issn1530-0447
dc.identifier.issue4en_US
dc.identifier.pmid37179436en_US
dc.identifier.scopus2-s2.0-85159295268en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1341en_US
dc.identifier.urihttps://doi.org/10.1038/s41390-023-02643-w
dc.identifier.urihttps://hdl.handle.net/11616/101352
dc.identifier.volume94en_US
dc.identifier.wosWOS:000986400900003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofPediatric Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInhaled Nitric-Oxideen_US
dc.subjectBronchopulmonary Dysplasiaen_US
dc.subjectAlveolar Macrophagesen_US
dc.subjectKappa-Ben_US
dc.subjectPreventionen_US
dc.subjectProtectsen_US
dc.subjectFutureen_US
dc.titleMolsidomine decreases hyperoxia-induced lung injury in neonatal ratsen_US
dc.typeArticleen_US

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