Deneysel subaraknoid kanamada Oktreotid asetatın serebral vazospazma etkisi
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Dosyalar
Tarih
2000
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Türk Nöroşirürji Dergisi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu çalIşmada,tavşan deneysel subaraknoid kanama
(SAK) modelinde, vazospazmll1 onlenmesi amaoyla
sentetik bir somatostatin analogu olan oktreotid asetat
(OA) kullal1lldl. Tedavi somasl baziller arter yuzey alal1l
olçumleri stereolojik goruntu analiz metoduyla yaplldl.
Yuzey alal1lolçumsonuçlan kontrol grubunda 323±48~m2
X 103, tedavisiz SAK grubunda 111±7~m2 X 103,
plasebo+SAK grubunda 115±5 ~m2 X 103, 150 ~gr / gun
OA+SAK grubunda 196±17~m2 X 103 olarak olçiildii.
Tedavi verilen ve verilmeyen gruplar arasl farklar istatiksel
yonden anlamh olarak bulundu. Bu deneysel çalIşmaOA
tedavisinin SAK'tan sonra serebral vazospazmll1
onlenmesinde etkili oldugunu duşundiirmektedir. Yan
etki profilinin oldukça duşuk olmasl ve subkutan yolla
kullal1llabilmesi diger avantajlandu. Ancak bu deneysel
çahşmanll1 sonuçlanmn diger klinik ve laboratuvar
çalIşmalarla da desteklenmesi gerekmektedir.
In this study, octreotid acetate (OA), a synthetic analog of somatostatin was used for the prevention of vasospasm in the experimental rabbit basilar artery subarachnoid hemorrhage (SAH) model. Basilar artery cross-sectional area was measured by using stereological image analysing method as 323±48 ~m2 X 103 for the control group, 111±7 ~m2X 103 for untreated SAH group, 115±5 ~m2X 103 for the placebo+SAH group, and 196±17 ~lm2X 103 for the 150~gr / day OA+SAH group. Differences between the values of treated and untreated groups were statistically significant. Our results suggest that OA treatment can be effective in the prevention of cerebral vasospasm after SAH. Low side effect profile and practical subcutaneous use are other advantages. The results of other clinical and laboratory researchs are necessary to support this experimental results.
In this study, octreotid acetate (OA), a synthetic analog of somatostatin was used for the prevention of vasospasm in the experimental rabbit basilar artery subarachnoid hemorrhage (SAH) model. Basilar artery cross-sectional area was measured by using stereological image analysing method as 323±48 ~m2 X 103 for the control group, 111±7 ~m2X 103 for untreated SAH group, 115±5 ~m2X 103 for the placebo+SAH group, and 196±17 ~lm2X 103 for the 150~gr / day OA+SAH group. Differences between the values of treated and untreated groups were statistically significant. Our results suggest that OA treatment can be effective in the prevention of cerebral vasospasm after SAH. Low side effect profile and practical subcutaneous use are other advantages. The results of other clinical and laboratory researchs are necessary to support this experimental results.
Açıklama
Anahtar Kelimeler
Oktreotid asetat, Serebral vazospazm, Subaraknoid kanama, Cerebral vasospasm, Octreotid acetate, Subarachnoid hemorrhage
Kaynak
Türk Nöroşirürji Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
10
Sayı
Künye
Çokluk, C. Şenel, A. Tümkaya, L. İyigün, Ö. L. Önder, A. Rakunt, C. Çelik, F. (2000). Deneysel Subaraknoid kanamada Oktreotid asetatın serebral vazospazma etkisi . Türk Nöroşirürji Dergisi, (10); 16–25.
