Development of Some Antiplatelet Salts as Drug Active Ingredients and Investigation Biological Activities

Basit Öğe Kaydı
dc.authoridSatilmis, Basri/0000-0002-2538-5774
dc.authoridUSLU, HARUN/0000-0001-8827-8557
dc.authoridKamisli, Suat/0000-0003-4281-3301
dc.authorwosidSatilmis, Basri/JBR-9078-2023
dc.authorwosidUSLU, HARUN/P-3681-2019
dc.authorwosidKamisli, Suat/JZT-8388-2024
dc.contributor.authorUslu, Harun
dc.contributor.authorSatilmis, Basri
dc.contributor.authorUyumlu, Ayse Burcin
dc.contributor.authorSaglik, Begum Nurpelin
dc.contributor.authorLevent, Serkan
dc.contributor.authorOzkay, Yusuf
dc.contributor.authorGenc, Metin Fikret
dc.date.accessioned2024-08-04T20:54:58Z
dc.date.available2024-08-04T20:54:58Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, prasugrel and prasugrel salts: prasugrel + trans-1,2-cyclohexanedicarboxylic acid (1a), prasugrel + maleic acid (2a), prasugrel + citric acid (3a), prasugrel + oxalic acid (4a), and prasugrel + trometamol (5a) were synthesized and investigated for their biological activities.Ex vivo antiplatelet and in vitro cytotoxic activities were experimentally researched. Antiproliferative activity was not observed for prasugrel and prasugrel salts, and it was also determined that there was no cytotoxic effect. Ex vivo experiments were carried out on diabetic and nondiabetic rats. When the study results were examined, 2a and 3a were seen to be effective prasugrel salts for antiplatelet activity.en_US
dc.description.sponsorshipSAN-TEZ Project; Republic of Turkey Ministry of Science Industry and Technology General Directorate of Science and Technology; [0122.STZ.2013 - 1]en_US
dc.description.sponsorshipThis research was funded by SAN-TEZ Project (Project No: 0122.STZ.2013 - 1) with the support of the Republic of Turkey Ministry of Science Industry and Technology General Directorate of Science and Technology, in cooperation with & Yacute;nonu University and Abdi Ibrahim Pharmaceuticals.en_US
dc.identifier.doi10.1007/s11094-024-03032-1
dc.identifier.endpage1270en_US
dc.identifier.issn0091-150X
dc.identifier.issn1573-9031
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-85181684759en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1260en_US
dc.identifier.urihttps://doi.org/10.1007/s11094-024-03032-1
dc.identifier.urihttps://hdl.handle.net/11616/101761
dc.identifier.volume57en_US
dc.identifier.wosWOS:001137703700004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPharmaceutical Chemistry Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPrasugrelen_US
dc.subjectPrasugrel saltsen_US
dc.subjectantiplateleten_US
dc.subjectcytotoxicen_US
dc.subjectdiabetesen_US
dc.titleDevelopment of Some Antiplatelet Salts as Drug Active Ingredients and Investigation Biological Activitiesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu