Effects of exercise on netrin-1 and TNF-α levels in non-inflammatory conditions
| dc.contributor.author | Kizildag, Servet | |
| dc.contributor.author | Yuksel, Oguz | |
| dc.contributor.author | Hosgorler, Ferda | |
| dc.contributor.author | Koc, Basar | |
| dc.contributor.author | Kandis, Sevim | |
| dc.contributor.author | Guvendi, Guven | |
| dc.contributor.author | Uysal, Nazan | |
| dc.date.accessioned | 2022-03-08T16:32:21Z | |
| dc.date.available | 2022-03-08T16:32:21Z | |
| dc.date.issued | 2020 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Aim: Exercise has been shown to increase netrin-1 expression and decrease TNF-α response in inflammatory conditions. However, the effect of exercise on netrin-1 and TNF-α levels in non-inflammatory conditions has not yet been explicated. The objective of this study was to investigate the effect of exercise on netrin-1 levels in relation to TNF-α.Material and Methods: The exercise group (n=6) consisted of 6 male Balb-c mice that were kept in cages with access to a running wheel for 6 weeks. The control group (n = 6) was kept in cages without a running wheel for the same time period. At the end of 6 weeks, both groups were sacrificed. Netrin-1 and TNF-α levels of the muscle, brain, and kidney tissues were measured.Results: Netrin-1 and TNF-α levels were not different between the two groups in all tissues. Netrin-1 and TNF-α levels were correlated in the brain, muscle, and kidney tissues of the exercise group and the muscle and kidney tissues of the control group.Conclusion: In non-inflammatory conditions netrin-1 and TNF-α levels are correlated in muscle and kidney tissues but not in brain tissues. Exercise does not affect netrin-1 and TNF-α levels of muscle and kidney tissues but induces a correlation between netrin-1 and TNF-α levels of brain tissue. | en_US |
| dc.identifier.citation | Yuksel, O., Kizildag, S., Hosgorler, F., Koc, B., Kandis, S., Guvendi, G., & Uysal, N. (2021). Effects of exercise on netrin-1 and TNF-α levels in non-inflammatory conditions . Annals of Medical Research | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/54875 | |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Annals of Medical Research | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Effects of exercise on netrin-1 and TNF-α levels in non-inflammatory conditions | en_US |
| dc.type | Article | en_US |
