Protective role of Diospyros lotus on cisplatin induced changes in sperm characteristics testicular damage and oxidative stress in rats

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dc.authoridTR123451en_US
dc.authoridTR52354en_US
dc.authoridTR103979en_US
dc.authoridTR102040en_US
dc.authoridTR23320en_US
dc.contributor.authorSaral, Sinan
dc.contributor.authorÖzçelik, E
dc.contributor.authorSaral, O.
dc.contributor.authorÇetin, Aslı
dc.contributor.authorBaşak, Neşe
dc.contributor.authorÇiftçi, Osman
dc.contributor.authorAydın, Muhterem
dc.date.accessioned2017-04-17T10:45:52Z
dc.date.available2017-04-17T10:45:52Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the protective effect of Diospyros lotus (DL) on cisplatin (CP)-induced testicular damage in male rats. Twenty-eight male rats were randomly divided into four groups: group 1 – control, given isotonic saline solution; group 2 – CP 7 mg kg 1 given intraperitoneally as single dose; group 3 – DL 1000 mg kg 1 per day given orally for 10 days; group 4 – CP and DL given together at the same doses. CP caused a significant increase in thiobarbituric acid-reactive substances (TBARS) level and a significant decrease in superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and glutathione (GSH) levels in rats testis tissues compared to the control group. CP caused a significant increase in lipid peroxidation in testis tissues compared to the control group, whereas DL led to a significant increase in SOD and GSH levels. However, there were no statistically significant changes in GPx and CAT levels. In addition, serum testosterone levels, sperm concentration and sperm motility were significantly decreased, but abnormal sperm rate and histological changes were increased with CP. However, these effects of CP on sperm parameters, histological changes and the tissue weights were eliminated by DL treatment. In conclusion, our study showed that the reproductive toxicity caused by CP may be prevented by DL treatment.en_US
dc.identifier.citationSaral, S. Özçelik, E. Saral, O. Çetin, A. Başak, N. Çiftçi, O. Aydın, M. (2016). Protective role of Diospyros lotus on cisplatin induced changes in sperm characteristics testicular damage and oxidative stress in rats. Andrologia, , 48, 308–317.en_US
dc.identifier.doi10.1111/and.12448en_US
dc.identifier.endpage317en_US
dc.identifier.issue48en_US
dc.identifier.startpage308en_US
dc.identifier.urihttps://hdl.handle.net/11616/6672
dc.language.isoenen_US
dc.publisherAndrologiaen_US
dc.relation.ispartofAndrologiaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCisplatinen_US
dc.subjectDiospyros lotusen_US
dc.subjectOxidative stressen_US
dc.subjectTesticular damageen_US
dc.titleProtective role of Diospyros lotus on cisplatin induced changes in sperm characteristics testicular damage and oxidative stress in ratsen_US
dc.typeArticleen_US

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