Effects of CAPE on biochemical, histopathological and cardiac parameters in doxorubicin induced cardiotoxicity

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dc.contributor.authorDisli, Olcay Murat
dc.contributor.authorAkca, Baris
dc.contributor.authorErdil, Nevzat
dc.contributor.authorOzhan, Onural
dc.contributor.authorDurhan, Merve
dc.contributor.authorYildiz, Azibe
dc.contributor.authorUlutas, Zeynep
dc.date.accessioned2026-04-04T13:33:01Z
dc.date.available2026-04-04T13:33:01Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractOBJECTIVE: In this study, the protective effect of Caffeic acid phenethyl ester (CAPE) against doxorubicin (DOX)-induced cardiotoxicity was investigated by evaluating oxidative stress parameters, ECG changes, matrix metalloproteinase 2 (MMP-2) gene expression, troponin I level and histopathology in Wistar Albino rats. METHODS: Forty rats were divided into 4 groups (n=10) including control (saline (vehicle for DOX) and 2.5% ethanol (vehicle for caffeic acid phenethyl ester), CAPE only (10 mu mol/kg bw), DOX only (10 mg/kg bw) and CAPE+DOX groups. Molecular, biochemical and histopathological analyses were performed on blood and heart tissues. RESULTS: No alterations were observed in oxidative stress parameters and MMP-2 gene expression of DOX and CAPE+DOX groups compared to control. Troponin I levels were higher in DOX and CAPE+DOX groups than in the control. Variable ECG changes were observed in the experimental groups such as increased systolic blood pressure, decreased QRS and QT interval in DOX group compared to the control without any ameliorative effect of CAPE. The presence of dense degenerative cardiomyocytes in the myocardium of the DOX group was noted. DOX caused damage to cardiomyocytes. It was observed that CAPE showed a significant decrease in histopathological changes and histopathological scoring in the CAPE+DOX group compared to DOX group. CONCLUSION: CAPE treatment ameliorated histopathological changes induced by DOX while other parameters including oxidative stress, MMP-2 gene expression, Troponin I and ECG studied in our study were not altered remarkably.
dc.description.sponsorshipInonu University Scientific Research Project Unit (BAP) [TSA-2022-2881]; Turkiye
dc.description.sponsorshipThis research was supported by Inonu University Scientific Research Project Unit (BAP, TSA-2022-2881) , Turkiye.
dc.identifier.doi10.14744/nci.2025.29566
dc.identifier.endpage596
dc.identifier.issn2148-4902
dc.identifier.issn2536-4553
dc.identifier.issue5
dc.identifier.pmid41573070
dc.identifier.scopus2-s2.0-105022500339
dc.identifier.scopusqualityQ3
dc.identifier.startpage587
dc.identifier.urihttps://doi.org/10.14744/nci.2025.29566
dc.identifier.urihttps://hdl.handle.net/11616/108874
dc.identifier.volume12
dc.identifier.wosWOS:001615018200003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKare Publ
dc.relation.ispartofNorthern Clinics of Istanbul
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectCAPE
dc.subjectcardiotoxicity
dc.subjectdoxorubicin
dc.subjectrat
dc.titleEffects of CAPE on biochemical, histopathological and cardiac parameters in doxorubicin induced cardiotoxicity
dc.typeArticle

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