Liver lipid peroxidation and antioxidant capacity in cerulein-induced acute pancreatitis

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dc.authoridUyumlu, Ayşe Burçin/0000-0001-9517-9274
dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridBatcioglu, Kadir/0000-0001-6663-2287
dc.authorwosidUyumlu, Ayşe Burçin/ABH-5573-2020
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidBatcioglu, Kadir/Q-2424-2015
dc.contributor.authorBatcioglu, K.
dc.contributor.authorGul, M.
dc.contributor.authorUyumlu, A. B.
dc.contributor.authorEsrefoglu, M.
dc.date.accessioned2024-08-04T20:32:13Z
dc.date.available2024-08-04T20:32:13Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the role of oxidative damage in pancreatitis-induced hepatic injury. Thirty-five rats were divided into five groups (each of 7 rats): control, cerulein (100 mu g/kg body weight), cerulein and pentoxifylline (12 mg/kg body weight), cerulein plus L-NAME (10 mg/kg body weight) and cerulein plus L-arginine (160 mg/kg body weight). The degree of hepatic cell degeneration differed significantly between groups. Mean malondialdehyde levels were 7.00 +/- 2.29, 20.89 +/- 10.13, 11.52 +/- 4.60, 18.69 +/- 8.56, and 8.58 +/- 3.68 nmol/mg protein for the control, cerulein, pentoxifylline, L-NAME, and L-arginine groups, respectively. Mean catalase activity was 3.20 +/- 0.83, 1.09 +/- 0.35, 2.05 +/- 0.91, 1.70 +/- 0.60, and 2.85 +/- 0.47 U/mg protein for the control, cerulein, pentoxifylline, L-NAME, and L-arginine groups, respectively, and mean glutathione peroxidase activity was 0.72 +/- 0.25, 0.33 +/- 0.09, 0.37 +/- 0.04, 0.34 +/- 0.07 and 0.42 +/- 0.1 U/mg protein for the control, cerulein, pentoxifylline, L-NAME, and L-arginine groups, respectively. Cerulein-induced liver damage was accompanied by a significant increase in tissue malondialdehyde levels (P < 0.05) and a significant decrease in catalase (P < 0.05) and GPx activities (P < 0.05). L-arginine and pentoxifylline, but not L-NAME, protected against this damage. Oxidative injury plays an important role not only in the pathogenesis of AP but also in pancreatitis-induced hepatic damage.en_US
dc.identifier.doi10.1590/S0100-879X2009000900001
dc.identifier.endpage782en_US
dc.identifier.issn0100-879X
dc.identifier.issn1414-431X
dc.identifier.issue9en_US
dc.identifier.pmid19738983en_US
dc.identifier.scopus2-s2.0-71049141307en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage776en_US
dc.identifier.urihttps://doi.org/10.1590/S0100-879X2009000900001
dc.identifier.urihttps://hdl.handle.net/11616/94922
dc.identifier.volume42en_US
dc.identifier.wosWOS:000270233200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Bras Divulg Cientificaen_US
dc.relation.ispartofBrazilian Journal of Medical and Biological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute pancreatitisen_US
dc.subjectLiver injuryen_US
dc.subjectOxidative damageen_US
dc.subjectPentoxifyllineen_US
dc.subjectL-NAMEen_US
dc.subjectL-arginineen_US
dc.titleLiver lipid peroxidation and antioxidant capacity in cerulein-induced acute pancreatitisen_US
dc.typeArticleen_US

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