Dexpanthenol reduces diabetic nephropathy and renal oxidative stress in rats

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dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridTutun, Bugra/0000-0002-3803-0489
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.authorwosidElbe, Hulya/D-5261-2015
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidVardı, Nigar/C-9549-2018
dc.contributor.authorTutun, B.
dc.contributor.authorElbe, H.
dc.contributor.authorVardi, N.
dc.contributor.authorParlakpinar, H.
dc.contributor.authorPolat, A.
dc.contributor.authorGunaltili, M.
dc.contributor.authorGuclu, M. M.
dc.date.accessioned2024-08-04T20:45:30Z
dc.date.available2024-08-04T20:45:30Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHyperglycemia increases reactive oxygen species (ROS) and the resulting oxidative stress contributes to the development of diabetic complications. Dexpanthenol (Dxp) is the biological active form of pantothenic acid. We investigated whether Dxp administration could decrease oxidative stress as a way to treat renal complications of diabetes mellitus (DM). Thirty-two male Wistar albino rats were divided into four groups: control, Dxp, DM and DM + Dxp. Experimental diabetes was induced by a single dose of streptozotocin (STZ). After administration of STZ, the DM + Dxp group was administered 500 mg/kg Dxp intraperitoneally every day for 6 weeks. At the end of the study, blood glucose levels were measured and rats were sacrificed. Kidneys were embedded in paraffin, sectioned and stained with hematoxylin and eosin, and periodic acid-Schiff. The mean malondialdehyde levels, glutathione peroxidase, superoxide dismutase and catalase activities, and total antioxidant and total oxidant status also were measured. The control group was normal in histological appearance. We observed congestion, inflammation, glomerulosclerosis, tubular desquamation, loss of villi and hydropic degeneration in tubule cells in the DM group. Indicators of oxidative stress were elevated and antioxidant activity was reduced in the DM group compared to controls. In the DM + Dxp group, oxidative stress was decreased, antioxidant activity was increased and histopathological changes were reduced compared to the DM group. We found that Dxp exhibited ameliorative effects on STZ induced diabetic nephropathy by increasing antioxidant activity.en_US
dc.description.sponsorshipTurkish Scientific and Technological Research Council (TUBITAK) under Domestic University Students Research Projects Support Programme [2209-A/2012]en_US
dc.description.sponsorshipOur project was supported by Turkish Scientific and Technological Research Council (TUBITAK) under Domestic University Students Research Projects Support Programme, 2209-A/2012.en_US
dc.identifier.doi10.1080/10520295.2018.1508746
dc.identifier.endpage91en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue2en_US
dc.identifier.pmid30317873en_US
dc.identifier.scopus2-s2.0-85055128587en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage84en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2018.1508746
dc.identifier.urihttps://hdl.handle.net/11616/98499
dc.identifier.volume94en_US
dc.identifier.wosWOS:000467970800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDexpanthenolen_US
dc.subjectdiabetesen_US
dc.subjectnephropathyen_US
dc.subjectoxidative stressen_US
dc.subjectraten_US
dc.titleDexpanthenol reduces diabetic nephropathy and renal oxidative stress in ratsen_US
dc.typeArticleen_US

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