A Comparative Analysis of Psychiatric Symptoms in Parkinson's Disease Between Tremor-Dominant and Non-Tremor-Dominant Phenotypes

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dc.contributor.authorAkan, Mustafa
dc.contributor.authorCiplak, Sibel
dc.contributor.authorAdiguzel, Ahmet
dc.date.accessioned2026-04-04T13:30:52Z
dc.date.available2026-04-04T13:30:52Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground:There is currently no study comparing psychiatric symptoms in Parkinson's patients with tremor-dominant (TD) and non-tremor-dominant (NTD) phenotypes. Our research hypothesis suggests that patients with the TD phenotype would have higher levels of anxiety compared to those with the NTD phenotype. Objective:To test this hypothesis and fill the gap in the literature. Methods:The study included 128 patients, 77 in the TD group and 51 in the NTD group. After their neurological evaluation, the same psychiatrist interviewed them, and the Brief Symptom Inventory (BSI) and sociodemographic data form were administered. Results:The TD group had statistically significantly higher scores on the BSI total and anxiety scores (P < 0.001 for both analyses). Linear regression analysis revealed that being in the TD group was an independent risk factor for BSI total and anxiety scores (P < 0.001 for both analyses). Conclusions:The results of our study are noteworthy as they show higher psychiatric symptoms in the TD group, despite previous studies reporting worse prognosis in Parkinson's patients with NTD phenotypes. In addition, the presentation of psychiatric symptoms in Parkinson's disease appears to be linked to how the disease manifests clinically.
dc.description.sponsorshipFaculty of Medicine at Uludag University
dc.description.sponsorshipInfinite gratitude and warm regards to Dr. Nusret Ayaz, a graduate of the Faculty of Medicine at Uludag University in 2010.
dc.identifier.doi10.4103/neurol-india.Neurol-India-D-24-00415
dc.identifier.endpage1017
dc.identifier.issn0028-3886
dc.identifier.issn1998-4022
dc.identifier.issue5
dc.identifier.pmid40946283
dc.identifier.scopus2-s2.0-105016057242
dc.identifier.scopusqualityQ3
dc.identifier.startpage1012
dc.identifier.urihttps://doi.org/10.4103/neurol-india.Neurol-India-D-24-00415
dc.identifier.urihttps://hdl.handle.net/11616/108432
dc.identifier.volume73
dc.identifier.wosWOS:001571690900038
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofNeurology India
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectAnxiety
dc.subjectnon-tremor-dominant
dc.subjectParkinson's disease
dc.subjectphenotype
dc.subjectpsychiatric symptom
dc.subjecttremor-dominant
dc.titleA Comparative Analysis of Psychiatric Symptoms in Parkinson's Disease Between Tremor-Dominant and Non-Tremor-Dominant Phenotypes
dc.typeArticle

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