Novel N-heterocyclic carbene silver(I) complexes: Synthesis, structural characterization, antimicrobial and cytotoxicity potential studies

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dc.contributor.authorKaraca, Emine Ozge
dc.contributor.authorMizrak, Ebru
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorCetinkaya, Erdem
dc.contributor.authorKarci, Huseyin
dc.contributor.authorDundar, Muhammed
dc.contributor.authorOzdemir, Ilknur
dc.date.accessioned2026-04-04T13:35:07Z
dc.date.available2026-04-04T13:35:07Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractIn this study, a new series of 1-(2-ethylhexyl)-3-(alkyl)-5,6-dimethylbenzimidazol-2-ylidene]silver(I) complexes has been synthesized and investigated their in vitro antibacterial, antifungal and anticancer properties. All molecules were characterized by 1H NMR, 13C NMR, and IR spectroscopy techniques. In vitro antimicrobial activity of the synthesized compounds investigated in this work was tested against the reference strains: Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213) and Pseudomonas aeruginosa (ATCC 27853), Candida albicans (ATCC MYA-2876) and Candida glabrata (ATCC 2001). Anticancer properties of samples were evaluated against A549, HCT116 and BEAS-2B cells lines. All silver-NHC complexes showed antibacterial activity against the tested bacterial and fungal strains.
dc.description.sponsorshipTechnological and Scientific Research Council of Turkiye (TUBITAK) [121Z158]; Inonu University Research Fund [FBG-2021-2562]
dc.description.sponsorshipThe Technological and Scientific Research Council of Turkiye (TUBITAK) provided funding for this work (Project No: 121Z158) and the Inonu University Research Fund (FBG-2021-2562) .
dc.identifier.doi10.1016/j.ica.2024.122458
dc.identifier.issn0020-1693
dc.identifier.issn1873-3255
dc.identifier.orcid0000-0003-0110-9588
dc.identifier.orcid0000-0003-2094-9742
dc.identifier.orcid0000-0001-6325-0216
dc.identifier.orcid0000-0003-3201-3597
dc.identifier.orcid0000-0002-5709-1623
dc.identifier.orcid0000-0001-6325-0216
dc.identifier.orcid0000-0001-6509-2012
dc.identifier.scopus2-s2.0-85210536448
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.ica.2024.122458
dc.identifier.urihttps://hdl.handle.net/11616/109607
dc.identifier.volume577
dc.identifier.wosWOS:001372025000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Sa
dc.relation.ispartofInorganica Chimica Acta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectCatalysts
dc.subjectStructure analysis
dc.subjectAnticancer activity
dc.subjectAntimicrobial activity
dc.subject6-Dimethylbenzimidazole
dc.subjectN -Heterocyclic carbene
dc.subjectSilver complexes
dc.titleNovel N-heterocyclic carbene silver(I) complexes: Synthesis, structural characterization, antimicrobial and cytotoxicity potential studies
dc.typeArticle

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