EVALUATION OF BLOOD ZONULIN LEVELS, INFLAMMATORY PROCESSES AND NEURONAL CHANGES IN CHILDREN WITH AUTISM SPECTRUM DISORDER

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridkartalcı, şükrü/0000-0003-2560-0355
dc.authoridÇALIŞKAN DEMİR, ARZU/0000-0002-0835-380X
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidkartalcı, şükrü/ABI-1106-2020
dc.authorwosidÇALIŞKAN DEMİR, ARZU/ABG-9592-2020
dc.contributor.authorKartalci, Gulsen
dc.contributor.authorDemir, Arzu Caliskan
dc.contributor.authorKartalci, Sukru
dc.contributor.authorUremis, Nuray
dc.contributor.authorTurkoz, Yusuf
dc.date.accessioned2024-08-04T20:52:06Z
dc.date.available2024-08-04T20:52:06Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by symptoms such as limited, and repetitive behavior patterns and disordered social interaction and communication. The etiology of Autism Spectrum Disorder (ASD) is not clearly known, it has been emphasized that the immune-inflammatory system may also play a role in this disease. This study aimed to evaluate in intestinal permeability, food antigen-antibody levels, inflammatory processes, and neuron damage in patients with ASD. Subjects and methods: Thirty-five children between the ages of 3-12 with ASD and 35 controls were included in the study. Both participants' height and weight were measured, and the parents filled the Socio-demographic Data and the Gastrointestinal Systems (GIS) Symptoms Form. Venous blood samples were collected, and serum zonulin, anti-gliadin Ig A and Ig G, IL6, TNF-alpha, TGFJ3, S100B, and NSE levels were measured by ELISA. Results: Serum zonulin levels in the ASD group were found to be significantly lower. IL-6 and TGF-beta were found to be significantly higher in the ASD group. There was no difference between the two groups in terms of serum anti-gliadin Ig A and Ig G and TNF-alpha values. Also, GIS symptoms, NSE and SlOOB levels were found similar between two groups. Conclusions: Although findings showing low zonulin levels and increased inflammatory processes in ASD were found in this study, no difference was found in the parameters of brain damage. The findings show that intestinal permeability does not decrease in ASD and that inflammatory processes may play a role in ASD.en_US
dc.identifier.endpage287en_US
dc.identifier.issn0353-5053
dc.identifier.issn1849-0867
dc.identifier.issue2en_US
dc.identifier.pmid35772138en_US
dc.identifier.scopus2-s2.0-85133220108en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage279en_US
dc.identifier.urihttps://hdl.handle.net/11616/100757
dc.identifier.volume34en_US
dc.identifier.wosWOS:000821581100011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedicinska Nakladaen_US
dc.relation.ispartofPsychiatria Danubinaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectautismen_US
dc.subjectzonulinen_US
dc.subjectinflammationen_US
dc.subjectneuronal damageen_US
dc.subjectleaky guten_US
dc.titleEVALUATION OF BLOOD ZONULIN LEVELS, INFLAMMATORY PROCESSES AND NEURONAL CHANGES IN CHILDREN WITH AUTISM SPECTRUM DISORDERen_US
dc.typeArticleen_US

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