Effects of iloprost on bleomycin-induced pulmonary fibrosis in rats compared with methyl-prednisolone

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dc.authoridHacievliyagil, Suleyman Savas/0000-0002-2572-1870
dc.authoridAytemur, Zeynep Ayfer/0000-0003-0421-907X
dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186;
dc.authorwosidHacievliyagil, Suleyman Savas/ABI-7307-2020
dc.authorwosidAytemur, Zeynep Ayfer/ABI-7452-2020
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidÖZEROL, ELİF/AAA-6707-2021
dc.contributor.authorAytemur, Z. Ayfer
dc.contributor.authorHacievliyagil, S. Savas
dc.contributor.authorIraz, M.
dc.contributor.authorSamdanci, E.
dc.contributor.authorOzerol, E.
dc.contributor.authorKuku, I.
dc.contributor.authorNurkabulov, Z.
dc.date.accessioned2024-08-04T20:37:33Z
dc.date.available2024-08-04T20:37:33Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Prostacyclin (PGI2) has been shown to inhibit the expression of pro-inflammatory and pro-fibrotic mediators in pulmonary fibrosis. In this study, we aimed to test the preventive effects of intraperitoneally administered iloprost, a stable PGI2 analog, on bleomycin-induced pulmonary fibrosis in rats and to compare the effects of iloprost with the effects of methylprednisolone, a traditional therapy. Methods: Rats were randomly allocated into four groups: 1. Saline alone (n = 6); 2. Bleomycin + placebo (n = 7); 3. Bleomycin + methyl-prednisolone (n = 7); 4. Bleomycin + iloprost (n = 7). Fibrotic changes in the lungs were demonstrated by analyzing the cellular composition of bronchoalveolar lavage fluid, histological evaluation and lung hydroxyproline content. Results: Fibrosis was made in the lungs of rats by bleomycin experimentally. Fibrosis scores in the methyl-prednisolone and the iloprost groups were significantly lower than in the placebo group (p < 0.05). Furthermore, the score of the iloprost group was significantly lower than the score of the methyl-prednisolone group. The hydroxyproline content was significantly less in the methyl-prednisolone and the iloprost groups (p < 0.05). In the placebo group, the neutrophil percentage in bronchoalveolar lavage was significantly higher than in the other groups, whereas the macrophage percentage in placebo group was significantly lower (p < 0.05). Conclusion: Iloprost has protective effect on the pulmonary fibrosis induced by bleomycin and it may be more effective in decreasing fibrotic changes than methyl-prednisolone. (C) 2011 Sociedade Portuguesa de Pneumologia. Published by Elsevier Espana, S. L. All rights reserved.en_US
dc.identifier.doi10.1016/j.rppneu.2012.04.010
dc.identifier.endpage277en_US
dc.identifier.issn0873-2159
dc.identifier.issue6en_US
dc.identifier.pmid22770817en_US
dc.identifier.scopus2-s2.0-84876807442en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage272en_US
dc.identifier.urihttps://doi.org/10.1016/j.rppneu.2012.04.010
dc.identifier.urihttps://hdl.handle.net/11616/96030
dc.identifier.volume18en_US
dc.identifier.wosWOS:000310782800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Doyma Slen_US
dc.relation.ispartofRevista Portuguesa De Pneumologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPulmonary fibrosisen_US
dc.subjectBleomycinen_US
dc.subjectIloprosten_US
dc.subjectMethyl-prednisoloneen_US
dc.subjectRatsen_US
dc.titleEffects of iloprost on bleomycin-induced pulmonary fibrosis in rats compared with methyl-prednisoloneen_US
dc.typeArticleen_US

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