Oxidant and Antioxidant Activity in Rabbit Livers Treated With Zoledronic Acid

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dc.authoridKIRAN, TUGBA RAIKA/0000-0002-3724-0249
dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authoridOtlu, Onder/0000-0001-5958-7609
dc.authoridGurocak, Asc Prof Simay/0000-0002-3707-5183
dc.authoridKıran, Tugba Raika/0000-0002-3724-0249
dc.authoridKarabulut, Ertugrul/0000-0002-5433-591X
dc.authorwosidKIRAN, TUGBA RAIKA/AAA-8224-2021
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.authorwosidOtlu, Onder/W-3887-2018
dc.authorwosidGurocak, Asc Prof Simay/N-3351-2014
dc.authorwosidKıran, Tugba Raika/HFZ-9643-2022
dc.authorwosidKarabulut, Ertugrul/AAA-7520-2021
dc.contributor.authorKarabulut, A. B.
dc.contributor.authorGui, M.
dc.contributor.authorKarabulut, E.
dc.contributor.authorKiran, T. R.
dc.contributor.authorOcak, S. G.
dc.contributor.authorOtlu, O.
dc.date.accessioned2024-08-04T20:32:37Z
dc.date.available2024-08-04T20:32:37Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractZoledronic acid (ZA), a nitrogen-bearing bisphosphonate, is used to treat the hypercalcemia associated with cancer. In addition to its antiumor effects, it acts as an osteoclast inhibitor. To investigate the effects of ZA on oxidative stress and antioxidants, we studied reduced glutathione (GSH) and antioxidant gamma glutamate cysteine, including nitrite and nitrate, which are endproducts of nitric oxide (NO) as well as malondialdehyde (MDA) in rabbit liver tissue. In the study ZA (100 mu g/kg) was administered to 7 rabbits that were fed ad libitum for comparison with untreated controls. MDA was studied using Thiobarbituric acid-reactive substance reduction, NO using cadmium reduction, GSH using an enzymatic method yielding dithinitrobenzene yellow substance. We observed significantly higher MDA and NO levels in the ZA group (P < .0001), whereas GSH levels were significantly lower (P < .0001). Tissues were examined histopathologically. According to our results we find ZA induced rabbit liver oxidative stress and decreases with antioxidant levels in liver tissue. Further studies are needed to explore the safe use of this agent.en_US
dc.identifier.doi10.1016/j.transproceed.2010.06.017
dc.identifier.endpage3822en_US
dc.identifier.issn0041-1345
dc.identifier.issue9en_US
dc.identifier.pmid21094863en_US
dc.identifier.scopus2-s2.0-78649452171en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage3820en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2010.06.017
dc.identifier.urihttps://hdl.handle.net/11616/95195
dc.identifier.volume42en_US
dc.identifier.wosWOS:000284969800086en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBisphosphonate Treatmenten_US
dc.subjectBone-Fracturesen_US
dc.subjectDouble-Blinden_US
dc.subjectTransplantationen_US
dc.subjectEventsen_US
dc.titleOxidant and Antioxidant Activity in Rabbit Livers Treated With Zoledronic Aciden_US
dc.typeArticleen_US

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