Ultra-structural and histopathological features of liver biopsy taken during laparotomy to confirm the diagnosis of biliary atresia

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dc.authoridZARARSIZ, GOKMEN/0000-0001-5801-1835
dc.authoridDemircan, Mehmet/0000-0002-4022-1276
dc.authoridGÜRÜNLÜOĞLU, Kubilay/0000-0002-8315-1765
dc.authoridVarol, İlknur fatma/0000-0001-5212-218X
dc.authorwosidZARARSIZ, GOKMEN/ABH-7959-2020
dc.authorwosidDemircan, Mehmet/B-1904-2008
dc.authorwosidGÜRÜNLÜOĞLU, Kubilay/AAO-5631-2020
dc.authorwosidVarol, İlknur fatma/ABH-6387-2020
dc.contributor.authorGurunluoglu, Semra
dc.contributor.authorGul, Mehmet
dc.contributor.authorZararsiz, Gokmen
dc.contributor.authorAkpinar, Necmettin
dc.contributor.authorVarol, Fatma, I
dc.contributor.authorDemircan, Mehmet
dc.contributor.authorGurunluoglu, Kubilay
dc.date.accessioned2024-08-04T20:52:13Z
dc.date.available2024-08-04T20:52:13Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Neonatal cholestasis is caused by a group of diseases that cause jaundice, which can be encountered in the neonatal period. Biliary atresia (BA) and idiopathic neonatal hepatitis (INH) are among neonatal cholestasis diseases. Aims: The aim of this study was to perform histopathological and ultra-structural examinations of liver biopsy tissue samples from BA and INH patients with liver biopsies taken during laparotomy to confirm the diagnosis of biliary atresia. Settings and Design: A total of patients undergoing Kasai surgery before the age of 60 days were included in an early group (n = 7), whereas patients undergoing surgery after the age of 60 days were included in a late group (n = 11). The control group (n = 11) included INH patients. Materials and Methods: For histopathological examinations, liver tissue samples obtained intra-operatively were subjected to routine histopathological procedures after being stained with caspase-3 and cytokeratin-7 antibodies. Ultra-structural evaluations were also performed. Statistical analysis used: For comparisons between the groups, a one-way analysis of variance (ANOVA) test and the Mann-Whitney U test were used for continuous variables. Results: Histopathological findings reflected the specific liver pathologic findings seen in biliary atresia. Although there was no significant difference between the BA groups, these parameters were not detected in the control group. The histopathological evaluations revealed no significant differences in the findings of liver parenchyma damage between the early, late, and control groups. Electron microscopic examinations showed that the patients in the late group had more severe signs of intra-cellular damage to the liver. Conclusions: Although the histopathological examination revealed no significant differences in liver damage between the three groups, in ultra-structural evaluation, intra-cellular damage was found to be less in groups with better prognosis. Electron microscopy evaluations of intra-cellular damage may be more useful in this respect.en_US
dc.identifier.doi10.4103/ijpm.ijpm_1057_21
dc.identifier.endpage580en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.issue3en_US
dc.identifier.pmid35900484en_US
dc.identifier.scopus2-s2.0-85135421669en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage572en_US
dc.identifier.urihttps://doi.org/10.4103/ijpm.ijpm_1057_21
dc.identifier.urihttps://hdl.handle.net/11616/100821
dc.identifier.volume65en_US
dc.identifier.wosWOS:000935829800009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal of Pathology and Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiliary atresiaen_US
dc.subjectcomparative histologyen_US
dc.subjectelectron microscopyen_US
dc.subjectliveren_US
dc.subjectpathologyen_US
dc.titleUltra-structural and histopathological features of liver biopsy taken during laparotomy to confirm the diagnosis of biliary atresiaen_US
dc.typeArticleen_US

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