Effects of caffeic acid phenethyl ester and epidermal growth factor on the development of caustic esophageal stricture in rats

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dc.authoridKutlu, Ramazan/0000-0001-7941-7025
dc.authoridMutus, Huseyin Murat/0000-0002-0059-1336
dc.authoridOZYURT, Huseyin/0000-0003-2327-4082
dc.authoridAYDIN, Nasuhi/0000-0003-3145-2432
dc.authorwosidKutlu, Ramazan/B-1624-2016
dc.authorwosidKARAMAN, Abdurrahman/G-7825-2016
dc.authorwosidMutus, Huseyin Murat/AAA-2357-2020
dc.authorwosidAYDIN, Nasuhi Engin/L-1607-2019
dc.authorwosidGürbüz, Necla/H-8965-2018
dc.authorwosidAydin, Nasuhi E/B-6536-2012
dc.authorwosidOZYURT, Huseyin/N-4351-2015
dc.contributor.authorKoltuksuz, U
dc.contributor.authorMutus, HM
dc.contributor.authorKutlu, R
dc.contributor.authorÖzyurt, H
dc.contributor.authorÇetin, S
dc.contributor.authorKaraman, A
dc.contributor.authorGürbüz, N
dc.date.accessioned2024-08-04T20:12:13Z
dc.date.available2024-08-04T20:12:13Z
dc.date.issued2001
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/Purpose: An experimental study was performed to modify the healing response in caustic esophageal burns to prevent stricture development. Two different agents with different modes of actions, caffeic acid phenethyl ester (CAPE) and epidermal growth factor (EGF), were studied. CAPE has antiinflammatory, immunomodulatory, antioxidant, and antimitotic properties. EGF has known properties in supporting wound healing and in protecting esophagus from injuries. Methods: The model described by Gehanno and its modification by Liu was used to create standard esophageal burns with 50% NaOH. The study was performed with 76 rats in 4 main groups (sham, CAPE, EGF, and control) and 2 subgroups in each for 5 and 28 days of observation. Efficacy of treatment was assessed in 28-day subgroups by measuring weight gain, contrast esophagograms on day 27, histologic evaluation by measuring stenosis index (wall thickness/lumen diameter), and collagen deposition, and biochemically by determining tissue hydroxy proline (OHP) content. Results: In the end of the study, increase rates of mean body weights of the animals in the 28-day subgroups were as follows: sham, 30%; CAPE, 23%; EGF, 22%; and control, 14%. Although all the animals in subgroups significantly gained weight, the mean weight gain was significantly low in controls when compared with sham, CAPE, and EGF groups (P < .05). Contrast esophagograms on day 27 showed no stenosis in the sham, mild stenosis in CAPE and EGF, and severe stenosis with proximal dilatation in controls. Stenosis indices of the subgroups were as follows: sham, 0.29; CAPE, 0.41; EGF, 0.41; control, 0.84. Index was significantly higher in controls (P < .05). Collagen accumulation scores in the esophageal wall were as follows: Sham, 0.0; CAPE, 0.87; EGF, 0.30; control, 2.70. Scores also were significantly higher in controls (P < .05). Tissue (OHP) levels were as follows (mg/g dry tissue): Sham, 1.48; CAPE, 1.53; EGF, 1.90; control, 4.01. Production of OHP was significantly higher in controls. Conclusions: The results of the parameters in the study indicate that administration of CAPE and EGF has beneficial effects in the prevention of caustic esophageal strictures. Those effects of CAPE may occur through its antiinflammatory, immunomodulatory, and antioxidant properties, and EGF may occur through its induced proliferative properties on the esophagus. Copyright (C) 2001 by WB. Saunders Company.en_US
dc.identifier.doi10.1053/jpsu.2001.27032
dc.identifier.endpage1509en_US
dc.identifier.issn0022-3468
dc.identifier.issue10en_US
dc.identifier.pmid11584397en_US
dc.identifier.scopus2-s2.0-0034805706en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1504en_US
dc.identifier.urihttps://doi.org/10.1053/jpsu.2001.27032
dc.identifier.urihttps://hdl.handle.net/11616/93287
dc.identifier.volume36en_US
dc.identifier.wosWOS:000171320000007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Coen_US
dc.relation.ispartofJournal of Pediatric Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcaustic esophageal strictureen_US
dc.subjectwound healingen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectepidermal growth factoren_US
dc.titleEffects of caffeic acid phenethyl ester and epidermal growth factor on the development of caustic esophageal stricture in ratsen_US
dc.typeArticleen_US

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