Evaluation of antibodies against hydatid cyst fluid antigens in the post-treatment follow-up of cystic echinococcosis patients

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dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X;
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.authorwosidOrmeci, Necati/K-1194-2018
dc.contributor.authorCelik, Tuncay
dc.contributor.authorAkarsu, Guelay Aral
dc.contributor.authorGungor, Cigdem
dc.contributor.authorColak, Cemil
dc.contributor.authorOrmeci, Necati
dc.date.accessioned2024-08-04T20:31:15Z
dc.date.available2024-08-04T20:31:15Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Cystic echinococcosis (CE), caused by the metacestode stage of Echinococcus granulosus, is one of the most important zoonoses worldwide. Long post-treatment follow-up is required because of possible relapse. The objective of this study was to determine the values of different antigenic fractions of sheep hydatid cyst fluid in the follow-up of CE patients after treatment. Material/Methods: After gradient gel electrophoresis of sheep hydatid cyst fluid, 45 post-treatment (1 month - 16 years) serum samples of CE patients treated with PAIR (puncture, aspirations, injection, and respiration) and five post-treatment (1 month) sera of operated CE patients were studied using Western blot. Twenty healthy individuals and five patients infected with other helminths served as controls. Results: Antigens with molecular weights of 6.5-8, 14, 20, 29, 45, 50, 66, 116-120, 205, and 215 kDa were identified. The bands detected at the highest frequency were 29 kDa (10.4%), 45 kDa (17.2%), and 66 kDa (12.8%). Sera of the 20 healthy controls recognized no specific bands. All of the sera of the five patients with other parasitic diseases recognized one or more hydatid cyst fluid antigens. There was a statistically significant difference between the time after treatment and band weights (p<0.0001). Conclusions: The protein bands of 29 and 205-215 kDa may be valuable in the follow-up of cystic echinococcosis patients as they disappear one year and six months, respectively, after therapy.en_US
dc.description.sponsorshipScientific & Technological Research Council of Turkey [SBAG-491]en_US
dc.description.sponsorshipThis study was supported by the Scientific & Technological Research Council of Turkey with the project code SBAG-491en_US
dc.identifier.endpageCR176en_US
dc.identifier.issn1643-3750
dc.identifier.issue4en_US
dc.identifier.pmid19333201en_US
dc.identifier.scopus2-s2.0-65949098897en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageCR170en_US
dc.identifier.urihttps://hdl.handle.net/11616/94804
dc.identifier.volume15en_US
dc.identifier.wosWOS:000266193900012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInt Scientific Information, Incen_US
dc.relation.ispartofMedical Science Monitoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcystic echinococcosisen_US
dc.subjectantigenen_US
dc.subjecttreatment follow-upen_US
dc.titleEvaluation of antibodies against hydatid cyst fluid antigens in the post-treatment follow-up of cystic echinococcosis patientsen_US
dc.typeArticleen_US

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