The Evaluation of Procalcitonin as a Diagnostic and Prognostic Marker of Bacterial Infections in Febrile Neutropenic Patients

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dc.authoridmemişoğlu, funda/0000-0003-3905-1182
dc.authorwosidmemişoğlu, funda/AAA-4392-2021
dc.contributor.authorYetkin, Funda
dc.contributor.authorSenol, Esin
dc.contributor.authorYalcin, Selim
dc.contributor.authorHaznedar, Rauf
dc.date.accessioned2024-08-04T20:35:41Z
dc.date.available2024-08-04T20:35:41Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to evaluate the role of procalcitonin (PCT) in the diagnosis, prognosis and follow-up of bacterial infections in febrile neutropenic patients in comparison to the standard parameter, C-reactive protein (CRP). Methods: 40 febrile neutropenic episodes of 37 patients with cancer undergoing chemotherapy were classified as fever of unknown origin (FUO), microbiologically or clinically documented infection. Four sequential serum samples were obtained at the onset of neutropenia, on the first and third days of fever and on the day of defervescence, or on day 5 or 7 of an unresolved fever. Results: At the onset of neutropenia, the PCT levels were found to be normal whereas CRP levels were found to be elevated in all patients. With the febrile episode, PCT levels were elevated in all types of infections which were significantly higher for documented infections compared to FUO (p< 0.05). Procalcitonin levels differed significantly between patients with and without severe sepsis (p<0.001), and the highest levels were seen on the third day of fever. PCT levels decreased rapidly in afebrile patients treated successfully, whereas they remained significantly higher for patients unresponsive to therapy (p<0.001). Conclusions: In conclusion, PCT could be suggested as a useful marker, and was superior to CRP for early diagnosis of documented infections, assessment of the severity of infection and response to therapy in febrile neutropenic patients.en_US
dc.identifier.doi10.5152/kd.2011.05
dc.identifier.endpage30en_US
dc.identifier.issn1301-143X
dc.identifier.issn1309-1484
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-83655164820en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage24en_US
dc.identifier.urihttps://doi.org/10.5152/kd.2011.05
dc.identifier.urihttps://hdl.handle.net/11616/95510
dc.identifier.volume24en_US
dc.identifier.wosWOS:000420898300005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherAvesen_US
dc.relation.ispartofKlimik Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFebrile neutropeniaen_US
dc.subjectbacterial infectionsen_US
dc.subjectC-reactive proteinen_US
dc.subjectprocalcitoninen_US
dc.titleThe Evaluation of Procalcitonin as a Diagnostic and Prognostic Marker of Bacterial Infections in Febrile Neutropenic Patientsen_US
dc.typeArticleen_US

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