Endotoxin exposure and puberty in female rats: the role of nitric oxide and caspase-1 inhibition in neonates

Basit Öğe Kaydı
dc.authoridVardı, Nigar/0000-0003-0576-1696;
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidElbe, Hulya/D-5261-2015
dc.authorwosidÖzgöçer, Tuba/AAA-1751-2021
dc.authorwosidYILDIZ, SEDAT/AAB-6354-2021
dc.contributor.authorOzgocer, Tuba
dc.contributor.authorYildiz, Sedat
dc.contributor.authorElbe, Hulya
dc.contributor.authorVardi, Nigar
dc.date.accessioned2024-08-04T20:40:23Z
dc.date.available2024-08-04T20:40:23Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBacterial toxins are widespread in the environment as well as in the digestive system of humans and animals. Toxin from Gram-negative bacteria (endotoxin or lipopolysaccharide; LPS) has a life-long programming effect on reproduction in rats, but the mediators have not been well-documented, so we investigated the effects of LPS on the timing of puberty in female rats. Because the levels of nitric oxide (NO) and interleukin 1 beta (IL-1 beta) increase following injection of LPS, we injected neonates (post-natal day (pnd) 7) with LPS, with or without NO or IL-1 beta inhibitors. Half of the prepubescent (pnd 30) animals received an additional LPS injection. Vaginal opening, number of ovarian follicles, and serum anti-LPS antibodies were determined. A single LPS injection was sufficient to reduce the primordial follicle pool, but puberty was delayed when rats received 2 LPS injections (at pnd 7 and 30). NO or IL-1 beta inhibitors improved both of these parameters, suggesting that the early detrimental effects of LPS on puberty and primordial follicle pool are mediated by NO and IL-1 beta.en_US
dc.description.sponsorshipScientific Research Project Unit (BAP) of Inonu University [2010-138]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Project Unit (BAP) of Inonu University (Project No.: 2010-138). We thank Professor Yusuf Turkoz for his help with the NO analyses, and Doctor Cemil Colak for his assistance with the statistical analyses. The authors declare that there is no conflict of interest associated with this study.en_US
dc.identifier.doi10.1139/cjpp-2014-0559
dc.identifier.endpage614en_US
dc.identifier.issn0008-4212
dc.identifier.issn1205-7541
dc.identifier.issue8en_US
dc.identifier.pmid26061900en_US
dc.identifier.scopus2-s2.0-84938635801en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage603en_US
dc.identifier.urihttps://doi.org/10.1139/cjpp-2014-0559
dc.identifier.urihttps://hdl.handle.net/11616/96891
dc.identifier.volume93en_US
dc.identifier.wosWOS:000359163800002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCanadian Science Publishing, Nrc Research Pressen_US
dc.relation.ispartofCanadian Journal of Physiology and Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectlipopolysaccharideen_US
dc.subjectpubertyen_US
dc.subjectovarian functionen_US
dc.subjectIL-1 betaen_US
dc.subjectnitric oxideen_US
dc.subjectfemale ratsen_US
dc.titleEndotoxin exposure and puberty in female rats: the role of nitric oxide and caspase-1 inhibition in neonatesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu