Characterization of a cDNA from Beta maritima that confers nickel tolerance in yeast
Yükleniyor...
Dosyalar
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Gene
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Nickel is an essential micronutrient due to its involvement in many enzymatic reactions as a cofactor. However,
excess of this element is toxic to biological systems. Here, we constructed a cDNA library from Beta maritima and
screened it in the yeast system to identify genes that confer resistance to toxic levels of nickel. A cDNA clone
(NIC6), which encodes for a putative membrane protein with unknown function, was found to help yeast cells
to tolerate toxic levels of nickel. A GFP fused form of Nic6 protein was localized to multivesicular structures in tobacco
epidermal cells. Thus, our results suggest a possible role of Nic6 in nickel and intracellular ion homeostasis.
Açıklama
Gene 538 (2014) 251–257
Anahtar Kelimeler
Nickel, Beta maritima, Yeast, Transporter protein, Lon homeostasis, Heavy metal toxicity
Kaynak
Gene
WoS Q Değeri
Scopus Q Değeri
Cilt
0
Sayı
0
Künye
Bozdag Gonensin O., Kaya Alaattin, Koc Ahmet, Noll Gundula A., Prüfer Dirk, Karakaya Hüseyin Caglar (2014). Characterization of a DNA from Beta maritima that confers nickel tolerance in yeast. Gene. 2014 Apr 1;538(2):251-7.
