The effects of magnesium sulphate on sevoflurane minimum alveolar concentrations and haemodynamic responses

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dc.authoridbegeç, zekine/0000-0002-9506-1871
dc.authoridErsoy, Mehmet/0000-0002-0724-2825
dc.authoridDurmus, Mahmut/0000-0001-9594-9064
dc.authorwosidbegeç, zekine/ABI-5491-2020
dc.authorwosidErsoy, Mehmet/ACN-2779-2022
dc.authorwosidDurmus, Mahmut/ABH-3006-2020
dc.contributor.authorDurmus, M
dc.contributor.authorBut, AK
dc.contributor.authorErdem, TB
dc.contributor.authorOzpolat, Z
dc.contributor.authorErsoy, MO
dc.date.accessioned2024-08-04T20:15:11Z
dc.date.available2024-08-04T20:15:11Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and objective: Magnesium administered before anaesthesia induction results in a significant reduction in intravenous anaesthetic consumption. The purpose of this study was to evaluate whether the dose of intravenous magnesium sulphate reduces the minimum alveolar anaesthetic concentration of sevoflurane for endotracheal intubation (MACE,) and skin incision (MAC), and attenuates haemodynamic responses. Methods: We studied 60 patients who were scheduled for elective surgery. Patients were not premedicated before induction of anaesthesia and were randomly assigned to receive intravenous saline 0.9% (Group I, n = 20) or magnesium sulphate 30 mg kg(-1) bolus + 10mg kg(-1) h(-1) continuous infusion (Group II, n = 20) or 50 mg kg(-1) bolus + 10 mg kg(-1) h(-1) continuous infusion (Group III, n = 20). Results: Median and 95% confidence limits for sevoflurane MAC(EI) were 2.68 (2.48-2.85), 2.88 (2.70-3.06) and 2.96 (2.70-3.16), and for sevoflurane MAC were 2.08 (1.76-2.40), 2.26 (2.08-2.47) and 2.40 (2.19-2.68) in Groups 1, 11 and 111, respectively. The differences in MACEI and MAC among groups were not statistically significant, except Group III in MAC study (P < 0.05). Mean arterial pressures and heart rate did not increase in Groups II and III after endotracheal intubation and skin incision. Conclusions: Magnesium sulphate administered before induction of anaesthesia increases MAC of sevoflurane and reduces cardiovascular responses to intubation.en_US
dc.identifier.doi10.1017/S0265021505001778
dc.identifier.endpage59en_US
dc.identifier.issn0265-0215
dc.identifier.issue1en_US
dc.identifier.pmid16390567en_US
dc.identifier.scopus2-s2.0-29844444889en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage54en_US
dc.identifier.urihttps://doi.org/10.1017/S0265021505001778
dc.identifier.urihttps://hdl.handle.net/11616/94208
dc.identifier.volume23en_US
dc.identifier.wosWOS:000235073800010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofEuropean Journal of Anaesthesiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmagnesiumen_US
dc.subjectphysiological measurement techniquesen_US
dc.subjectblood pressureen_US
dc.subjectheart rateen_US
dc.subjectanaesthetics inhalationalen_US
dc.subjectsevofluraneen_US
dc.subjectminimum alveolar concentrationen_US
dc.titleThe effects of magnesium sulphate on sevoflurane minimum alveolar concentrations and haemodynamic responsesen_US
dc.typeArticleen_US

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