The effect of aminoguanidine against cholestatic liver injury in rats

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dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridIsik, Burak/0000-0002-2395-3985
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidIsik, Burak/A-6657-2018
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.contributor.authorYilmaz, Mehmet
dc.contributor.authorAra, Cengiz
dc.contributor.authorIsik, Burak
dc.contributor.authorKaradag, Nese
dc.contributor.authorYilmaz, Sezai
dc.contributor.authorPolat, Alattin
dc.contributor.authorCoban, Sacit
dc.date.accessioned2024-08-04T20:30:39Z
dc.date.available2024-08-04T20:30:39Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe investigated the protective role of aminoguanidine (AG) in rat liver injury induced by chronic biliary obstruction. Secondary biliary cirrhosis was induced by bile duct ligation for 14 days. Swiss albino rats were divided into three groups: Common bile duct ligated (CBDL) rats; Group A, CBDL rats treated with AG as Group B and simple laparotomy group known as the Sham group; Group C. Group B received 200 mg/kg of AG intraperitoneally daily throughout 14 days. The present data showed decreased gama glutamyl transferase (GGT), aspartate aminotransferase (AST), bilirubin and alanine aminotransferase (ALT) levels in the AG treated rats, when compared with CBDL rats (p < 0.05). In the AG treated rats, tissue levels of malondialdehyde (MDA) were significantly lower than that in CBDL rats (p < 0.001). Although the levels of glutathione (GSH) in AG treated rats were higher and myeloperoxidase (MPO) were lower than that in CBDL rats, the difference was not statistically significant(p > 0.05). The levels of interieukin-l alpha\ (IL-1 alpha) and tumor necrosis factor-alpha (TNF alpha) were significantly lower and although the levels of interleukin-6 (IL-6) were lower in AG treated rats than that in CBDL rats, the difference was not statistically significant. Administration of AG in the rats with biliary obstruction resulted in inhibition of ductular proliferation and portal inflammation. The present study demonstrates that intraperitoneal administration of AG in CBDL rats maintains antioxidant defenses, reduces liver oxidative and cytokine damage and ductular proliferation and portal inflammation. This effect of AG may be useful in the preservation of liver injury in cholestasis. Copyright (C) 2006 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/cbf.1359
dc.identifier.endpage632en_US
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue6en_US
dc.identifier.pmid16892451en_US
dc.identifier.scopus2-s2.0-38449094385en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage625en_US
dc.identifier.urihttps://doi.org/10.1002/cbf.1359
dc.identifier.urihttps://hdl.handle.net/11616/94436
dc.identifier.volume25en_US
dc.identifier.wosWOS:000251002300005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Biochemistry and Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbile duct ligationen_US
dc.subjectaminoguanidineen_US
dc.subjectoxidative stressen_US
dc.subjectcytokineen_US
dc.titleThe effect of aminoguanidine against cholestatic liver injury in ratsen_US
dc.typeArticleen_US

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