Synthesis of some novel 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime ester derivatives and evaluation of their anticonvulsant activity

Basit Öğe Kaydı
dc.authoridalagoz, mehmet abdullah/0000-0001-5190-7196
dc.authoridKarakurt, Arzu/0000-0003-2209-0871
dc.authorwosidalagoz, mehmet abdullah/W-7847-2018
dc.authorwosidKarakurt, Arzu/ABH-9340-2020
dc.contributor.authorKarakurt, Arzu
dc.contributor.authorAlagoz, Mehmet A.
dc.contributor.authorSayoglu, Burcu
dc.contributor.authorCalis, Unsal
dc.contributor.authorDalkara, Sevim
dc.date.accessioned2024-08-04T20:36:10Z
dc.date.available2024-08-04T20:36:10Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTwenty-three new oxime ester derivatives of nafimidone were synthesized with the prospect of potential anticonvulsant activities. MES and ScM tests were employed for their anticonvulsant activities and rotorod test for neurological deficits. Eighteen compounds were found to be protective against MES seizures. Alkyl (1-8) and arylalkyl (9,10) oxime ester derivatives were found to be more active than aryl oxime ester derivatives (11-23). Five compounds (2, 3, 7, 9, 10), which were protective at 0.5 h at the doses of 30 mg/kg and higher in MES test, showed the highest activity. Compound 17 was the most active one in ScM test at all dose levels at 4 h. (C) 2012 Elsevier Masson SAS. All rights reserved.en_US
dc.description.sponsorshipHacettepe University Scientific Research Fund [06 D03 301 001]; TUBITAK [110S270]; Inonu University Scientific Researches Unit [2011/66]en_US
dc.description.sponsorshipThis project was supported by Hacettepe University Scientific Research Fund, (Project no: 06 D03 301 001), TUBITAK, (Project no: 110S270) and Inonu University Scientific Researches Unit (Project no: 2011/66).en_US
dc.identifier.doi10.1016/j.ejmech.2012.08.037
dc.identifier.endpage282en_US
dc.identifier.issn0223-5234
dc.identifier.pmid23085104en_US
dc.identifier.scopus2-s2.0-84867433214en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage275en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2012.08.037
dc.identifier.urihttps://hdl.handle.net/11616/95819
dc.identifier.volume57en_US
dc.identifier.wosWOS:000312621700029en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofEuropean Journal of Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxime esteren_US
dc.subject(arylalkyl)imidazoleen_US
dc.subjectAzole derivativesen_US
dc.subjectAnticonvulsant activityen_US
dc.subjectE/Z isomersen_US
dc.titleSynthesis of some novel 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime ester derivatives and evaluation of their anticonvulsant activityen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu