Investigation of Serum Interleukin 6, High-Sensitivity C-Reactive Protein and White Blood Cell Levels during the Diagnosis and Treatment of Paediatric Appendicitis Patients before and during the COVID-19 Pandemic

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dc.authorscopusid8867300500
dc.authorscopusid55257618200
dc.authorscopusid57197007210
dc.authorscopusid55049722500
dc.authorscopusid23768445000
dc.authorscopusid57208778562
dc.authorscopusid57190845490
dc.contributor.authorGürünlüoglu K.
dc.contributor.authorZararsiz G.
dc.contributor.authorAslan M.
dc.contributor.authorAkbas S.
dc.contributor.authorTekin M.
dc.contributor.authorGürünlüoglu S.
dc.contributor.authorBag H.
dc.date.accessioned2024-08-04T19:59:17Z
dc.date.available2024-08-04T19:59:17Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: In this study, we prospectively investigated changes in serum interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP) and full white blood cell (WBC) counts during the diagnosis and treatment of paediatric patients with appendicitis. We also investigated the effects of the COVID-19 pandemic on the diagnosis and treatment processes of paediatric appendicitis patients. Materials and Methods: A non-perforated appendicitis group (n = 110), a perforated appendicitis group (n = 35) and an appendicitis + COVID-19 group (n = 8) were formed. Blood samples were taken upon admission and every day until the three studied parameters returned to normal values. To investigate the effects of the COVID-19 pandemic on paediatric appendicitis patients, the perforated appendicitis rates and the times from the onset of the first symptoms to the operation before and during the pandemic were compared. Results: WBC, IL-6, and hsCRP dropped below the upper limits on the second postoperative day in the non-perforated appendicitis group, four to six days postoperatively in the perforated appendicitis group, and three to six days postoperatively in the appendicitis + COVID-19 group. These parameters were not within normal range in patients who developed complications during follow-up. The time from the onset of abdominal pain to the surgery was significantly longer during than before the pandemic in both the non-perforated appendicitis group and the perforated appendicitis group. Conclusions: Our results show that WBC, IL-6, and hsCRP are useful laboratory parameters that can complete clinical examinations in the diagnosis of appendicitis in paediatric patients and the identification of complications that may develop postoperatively. © 2023 Wolters Kluwer Medknow Publications. All rights reserved.en_US
dc.identifier.doi10.4103/ajps.ajps_128_21
dc.identifier.endpage137en_US
dc.identifier.issn0189-6725
dc.identifier.issue2en_US
dc.identifier.pmid36960509en_US
dc.identifier.scopus2-s2.0-85150928053en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage130en_US
dc.identifier.urihttps://doi.org/10.4103/ajps.ajps_128_21
dc.identifier.urihttps://hdl.handle.net/11616/90527
dc.identifier.volume20en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofAfrican Journal of Paediatric Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19 pandemicen_US
dc.subjecthigh-sensitivity C-reactive proteinen_US
dc.subjectinterleukin 6en_US
dc.subjectpaediatric appendicitisen_US
dc.subjectwhite blood cellen_US
dc.titleInvestigation of Serum Interleukin 6, High-Sensitivity C-Reactive Protein and White Blood Cell Levels during the Diagnosis and Treatment of Paediatric Appendicitis Patients before and during the COVID-19 Pandemicen_US
dc.typeArticleen_US

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