Melatonin Ameliorates Tacrolimus (FK-506)'s Induced Immunosupressive Effect in Rat Liver

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dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.contributor.authorKarabulut, A. B.
dc.contributor.authorAra, C.
dc.date.accessioned2024-08-04T20:31:15Z
dc.date.available2024-08-04T20:31:15Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTacrolimus (FK-506) is a powerful immunosuppressive agent that modulates neutrophil infiltration during inflammation. In this study, we sought to investigate the effects of melatonin on malondialdehyde (MDA), nitric oxide (NO), interleukin (IL)-6, and tumor necrosis factor-alpha (TNF-alpha) to oppose the negative effects of the immunosupressant FK-506. Group A was sham; group B, tacrolimus (1 mg/kg/d subcutaneously); and Group C received tacrolimus (1 mg/kg/d plus melatonin). All tissues underwent histopathologic examination. The MDA level in group B increased 53% compared with the sham group (P < .001); in group C, the MDA level decreased 1.6% compared with group B (P > .05). While TNF-alpha in group B increased 68.8% compared with the sham group (P < .001) and in group C it decreased 63.5% compared with the sham group. The IL-6 level in group B increased 81%; in group C, it decreased 13% compared with group B. NO levels in group B increased 48% compared with the sham group and increased by 15% in group B compared with group C. Thus melatonin may serve as a protective agent against the side effects of tacrolimus.en_US
dc.identifier.doi10.1016/j.transproceed.2008.12.035
dc.identifier.endpage1877en_US
dc.identifier.issn0041-1345
dc.identifier.issue5en_US
dc.identifier.pmid19545748en_US
dc.identifier.scopus2-s2.0-67249117772en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1875en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2008.12.035
dc.identifier.urihttps://hdl.handle.net/11616/94812
dc.identifier.volume41en_US
dc.identifier.wosWOS:000267449100097en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectTumor-Necrosis-Factoren_US
dc.subjectNitric-Oxideen_US
dc.subjectPineal-Glanden_US
dc.subjectFk506en_US
dc.subjectDamageen_US
dc.subjectTransplantationen_US
dc.subjectCyclosporineen_US
dc.subjectAntioxidanten_US
dc.subjectMetabolitesen_US
dc.titleMelatonin Ameliorates Tacrolimus (FK-506)'s Induced Immunosupressive Effect in Rat Liveren_US
dc.typeArticleen_US

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