Application of HPLC to investigate the physicochemical properties and intestinal permeability of Ketoprofen

Basit Öğe Kaydı
dc.authorscopusid14032701900
dc.authorscopusid16641914100
dc.authorscopusid57189516470
dc.authorscopusid56666885900
dc.authorscopusid55904870700
dc.contributor.authorKaynak M.S.
dc.contributor.authorÇelebier M.
dc.contributor.authorAkgeyik E.
dc.contributor.authorSahin S.
dc.contributor.authorAltınöz S.
dc.date.accessioned2024-08-04T20:02:29Z
dc.date.available2024-08-04T20:02:29Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: The main objective of this study was to investigate the effect of pH on the solubility and intestinal permeability of ketoprofen by using HPLC. Ketoprofen is a slightly soluble acidic drug, and its solubility in aqueous phase is affected by pH changes dramatically. However, there is no data in the literature to support whether this pH dependent water solubility of ketoprofen will influence its absorption/bioavailability. Method: In this study, the distribution-coefficient (log D) of ketoprofen at various pH values between 4.5 and 7.5 were investigated using HPLC, and then it was made an attempt to correlate the log D values with the intestinal permeability values. For this reason, in vivo intestinal permeability studies were performed at pH 4.5 and pH 7.5. The concentrations of model and reference compounds and also the blank buffers passed though the rat intestine were analyzed by means of a validated HPLC method. Result: A nonlinear relationship was found between the results of in vitro and in vivo studies indicating that the diffusion of ketoprofen was not only related with passive diffusion, but also could be related with active transport. © 2017 Bentham Science Publishers.en_US
dc.identifier.doi10.2174/1573412312666160422151409
dc.identifier.endpage79en_US
dc.identifier.issn1573-4129
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85018395938en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage72en_US
dc.identifier.urihttps://doi.org/10.2174/1573412312666160422151409
dc.identifier.urihttps://hdl.handle.net/11616/91731
dc.identifier.volume13en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publishers B.V.en_US
dc.relation.ispartofCurrent Pharmaceutical Analysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcid dissociation constanten_US
dc.subjectDiffusion coefficienten_US
dc.subjectHPLC (high-performance/pressure liquid chromatography)en_US
dc.subjectIntestinal permeabilityen_US
dc.subjectKetoprofenen_US
dc.subjectPhysicochemical propertiesen_US
dc.titleApplication of HPLC to investigate the physicochemical properties and intestinal permeability of Ketoprofenen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu