Protective effects of vitamin E against acrylamide-induced hepatotoxicity and nephrotoxicity from fetal development to adulthood: Insights into Akt/ NF-?B and Bcl-xL/Bax signaling pathways

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dc.authoridUremis, Muhammed Mehdi/0000-0003-2296-2422
dc.authorwosidÖZSOY, Eda Nur/AFX-9575-2022
dc.authorwosidUremis, Muhammed Mehdi/HKP-0531-2023
dc.contributor.authorUremi, Nuray
dc.contributor.authorUremi, Muhammed Mehdi
dc.contributor.authorGul, Mehmet
dc.contributor.authorOzsoy, Eda Nur
dc.contributor.authorTurkoz, Yusuf
dc.date.accessioned2024-08-04T20:55:00Z
dc.date.available2024-08-04T20:55:00Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAcrylamide (ACR), a toxin present in fried and baked carbohydrate-rich foods, is known to cause liver and kidney damage. This study aimed to investigate the mechanisms of oxidative stress, inflammation, and apoptosis that contribute to liver and kidney damage induced by chronic administration of ACR. Additionally, the effectiveness of vitamin E in mitigating these toxic effects was examined. The study initially involved dividing 40 pregnant rats into four groups. After lactation, the research continued with male offspring rats from each group. The offspring rats were divided into Control, Vitamin E, ACR, and ACR + Vitamin E groups. Following ACR administration, liver and kidney function tests were performed on serum samples. Biochemical analyses, evaluation of inflammation markers, histopathological examination, and assessment of protein levels of Akt/I kappa B alpha/NF-kappa B, Bax, Bcl-xL, and Caspase-9 were conducted on liver and kidney tissues. The analysis demonstrated that ACR adversely affected liver and kidney function, resulting in oxidative stress, increased inflammation, and elevated apoptotic markers. Conversely, administration of vitamin E positively impacted these parameters, restoring them to control levels. Based on the results, the mechanism of ACR's action on oxidative stress and inflammation-induced liver and kidney damage may be associated with the activation of apoptotic markers such as Bax and Caspase-9, as well as the Akt/I kappa B alpha/NF-kappa B signaling pathway. Consequently, the protective properties of vitamin E establish it as an essential vitamin for the prevention or mitigation of various ACR-induced damages.en_US
dc.identifier.doi10.1016/j.tox.2024.153729
dc.identifier.issn0300-483X
dc.identifier.issn1879-3185
dc.identifier.pmid38242491en_US
dc.identifier.scopus2-s2.0-85183036441en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.tox.2024.153729
dc.identifier.urihttps://hdl.handle.net/11616/101775
dc.identifier.volume502en_US
dc.identifier.wosWOS:001170711000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofToxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcrylamideen_US
dc.subjectLiver and kidneyen_US
dc.subjectOxidative stressen_US
dc.subjectInflammationen_US
dc.subjectApoptosisen_US
dc.subjectVitamin Een_US
dc.titleProtective effects of vitamin E against acrylamide-induced hepatotoxicity and nephrotoxicity from fetal development to adulthood: Insights into Akt/ NF-?B and Bcl-xL/Bax signaling pathwaysen_US
dc.typeArticleen_US

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