Evaluation of Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio in patients with Behcet's disease

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dc.authoridHidayet, Şıho/0000-0002-4103-9345
dc.authoridTaşolar, Hakan/0000-0002-1249-7240
dc.authoridgurel, gulhan/0000-0001-5716-8750
dc.authorwosidHidayet, Şıho/ABI-2256-2020
dc.authorwosidTuran, Yaşar/AAL-6084-2020
dc.authorwosidTaşolar, Hakan/ABG-4466-2020
dc.authorwosidgurel, gulhan/ACV-8295-2022
dc.contributor.authorHidayet, Siho
dc.contributor.authorDemir, Vahit
dc.contributor.authorTuran, Yasar
dc.contributor.authorGurel, Gulhan
dc.contributor.authorTasolar, Mehmet Hakan
dc.date.accessioned2024-08-04T20:46:44Z
dc.date.available2024-08-04T20:46:44Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Behcet's disease (BD), a multisystemic inflammatory disorder, has been associated with a number of cardiovascular dysfunctions, including ventricular arrhythmias and sudden cardiac death. The mechanism of increased ventricular arrhythmias in BD remains uncertain. The aim of the present study was to assess the ventricular repolarization by using the Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio as candidate markers of ventricular arrhythmias in patients with BD. Methods: A total of 42 patients (mean age: 42.71 +/- 10.99 years) with BD and 50 sex- and age-matched healthy volunteers (mean age: 39.24 +/- 11.32 years) as the control group were evaluated. The risk of ventricular arrhythmia was evaluated by calculating the electrocardiographic, the Tp-e interval, and the QT, QTc, Tp-e/QT, and Tp-e/QTc ratios. Results: Climax (p=0.005), QT cmax (p=0.015), QTmin (p=0.011), and QTcmin (p=0.024) were statistically significantly higher in the BD group than in the control group. The Tp-e, cTp-e, Tp-e/QT, and Tp-e/QTc ratios were also significantly higher in patients with BD than in the control group (80.26 +/- 4.55 and 74.74 +/- 6.47, respectively, p<0.001; 88.23 +/- 6.36 and 82.68 +/- 7.81, respectively, p<0.001; 0.21 +/- 0.01 and 0.20 +/- 0.01, respectively, p=0.008; and 0.19 +/- 0.01 and 0.18 +/- 0.01, respectively, p=0.01). Positive correlations were found between Tp-e/QTc ratio and disease duration (r=0.382, p=0.013). Conclusion: Our study showed that the Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio, which are evaluated electrocardiographically in patients with BD, have been prolonged compared with normal healthy individuals. A positive correlation was determined between disease duration and Tp-e/QTc ratio. These results may be indicative of an early subclinical cardiac involvement in patients with BD, considering the duration of the disease. Therefore, these patients should be more closely screened for ventricular a rrhythmias.en_US
dc.identifier.doi10.14744/AnatolJCardiol.2019.70019
dc.identifier.endpage90en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue2en_US
dc.identifier.pmid31375650en_US
dc.identifier.scopus2-s2.0-85070807886en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage85en_US
dc.identifier.urihttps://doi.org/10.14744/AnatolJCardiol.2019.70019
dc.identifier.urihttps://hdl.handle.net/11616/98914
dc.identifier.volume22en_US
dc.identifier.wosWOS:000482646600009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofAnatolian Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBehcet's diseaseen_US
dc.subjectTp-e intervalen_US
dc.subjectTp-e/QTd ratioen_US
dc.subjectventricular arrhythmiaen_US
dc.titleEvaluation of Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio in patients with Behcet's diseaseen_US
dc.typeArticleen_US

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