Association between survivin gene polymorphisms and the susceptibility to colon cancer development in the turkish population

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dc.authoridTR223147en_US
dc.authoridTR109090en_US
dc.authoridTR180669en_US
dc.authoridTR4412en_US
dc.contributor.authorYılmaz, Nesibe
dc.contributor.authorYaykaşlı, Kürşat Oğuz
dc.contributor.authorYılmaz, Ümit
dc.contributor.authorEröz, Recep
dc.contributor.authorUzunlar, Ali Kemal
dc.contributor.authorAnkaralı, Handan
dc.contributor.authorŞahiner, Cem
dc.contributor.authorBaltacı, Davut
dc.date.accessioned2017-04-14T06:28:34Z
dc.date.available2017-04-14T06:28:34Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Colon cancer is one of the most common cancers worldwide. Apoptosis is a necessary physiological process for cell elimination which is very important both cellular homeostasis and cell proliferation and differantiation. Dysregulation can lead to uncontrolled cell growth and tumor development. Survivin, a member of the IAP family, plays a key role in promotion of cell proliferation as well as inhibition of apoptosis in cancer cells. The aim of this study was to investigate whether specific genetic polymorphisms of survivin could be associated with colon cancer development and progression in a Turkish population. Our study is the first to our knowledge to investigate the relationship between colon cancer risk and survivin gene polymorphisms. Materials and Methods: The relation between colon cancer and survivin -31 G/C (rs9904341), -241 C/T (rs17878467) and -625 C/G (rs8073069) polymorphism in promotor site of survivin gene associated with apoptosis was investigated using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: Individuals with -31C allele and CC genotype were found to have a higher risk of developing colon cancer (OR=13.4, p=0.01). The -241 CT genotype considerably increased the risk of colon cancer (OR=12.0, p=0.0001). However, there was no significant varaition of the survivin -625 C/G polymorphism among colon cancer patients and controls in our study. Conclusions: This study provides the first evidence that survivin -31 G/C and -241 C/T SNP significantly contribute to the risk of colon cancer in the Turkish population.en_US
dc.identifier.citationYılmaz, N. Yaykaşlı, K. O. Yılmaz, Ü. Eröz, R. Uzunlar, A. K. Ankaralı, H. Şahiner, C. Baltacı, D. (2014). Association Between Survivin Gene Polymorphisms and the Susceptibility to Colon Cancer Development in the Turkish Population. Asian Pacific Journal of Cancer Prevention, 15(20), 8963–8967.en_US
dc.identifier.doi10.7314/APJCP.2014.15.20.8963en_US
dc.identifier.endpage8967en_US
dc.identifier.issn1513-7368
dc.identifier.issue20en_US
dc.identifier.startpage8963en_US
dc.identifier.urihttp://koreascience.or.kr/journal/view.jsp?kj=POCPA9&py=2014&vnc=v15n20&sp=8963
dc.identifier.urihttps://hdl.handle.net/11616/6663
dc.identifier.volume15en_US
dc.language.isoenen_US
dc.publisherAsian Pacific Journal of Cancer Preventionen_US
dc.relation.ispartofAsian Pacific Journal of Cancer Preventionen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectColon canceren_US
dc.subjectSurvivinen_US
dc.subjectPolymorphismen_US
dc.subjectPCRen_US
dc.subjectRFLPen_US
dc.subjectSusceptibilityen_US
dc.subjectTurkeyen_US
dc.titleAssociation between survivin gene polymorphisms and the susceptibility to colon cancer development in the turkish populationen_US
dc.typeArticleen_US

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