Long-term effects of levetiracetam and valproic acid on laboratory parameters in childhood epilepsy

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dc.contributor.authorAydın, Hilal
dc.contributor.authorKorkut, Oğuzhan
dc.contributor.authorBıçakcıoğlu, Işınsu
dc.contributor.authorDoğan, Merve
dc.date.accessioned2024-08-04T19:53:22Z
dc.date.available2024-08-04T19:53:22Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractEpilepsy is the most common neurological disorder in childhood which often requires long-term or sometimes lifelong treatment. In this study, we aimed to evaluate the change in hematological and biochemical laboratory parameters at the 24th month compared to the treatment baseline values in pediatric epilepsy patients receiving levetiracetam (LEV) and valproic acid (VPA) monotherapy. Complete blood count panel, biochemical and hormonal parameters were investigated retrospectively at baseline and at 24 months in patients diagnosed with epilepsy at the Balıkesir University Medical Faculty pediatric neurology clinic, Türkiye, and started on LEV and VPA monotherapy between 01.08.2019 and 01.08.2022. Forty-nine patients were using LEV and 14 VPA. A statistically significant difference in terms of the complete blood count parameters mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) was observed in the cases using LEV between baseline and the 24th month of treatment (p=0.006, p=0.004). Among the cases using VPA, significant differences between baseline and the 24th month of treatment were determined in the complete blood count parameters red blood cell (RBC), MCV, and monocyte (MON)% values (p=0.004, p=0.022, and p=0.01). In conclusion, epilepsy treatment is a lengthy process in pediatric patients, and patients need to be monitored using hematological and biochemical parameters at specific intervals in terms of potential seizure drug side effects.en_US
dc.identifier.doi10.5455/medscience.2023.10.213
dc.identifier.endpage191en_US
dc.identifier.issn2147-0634
dc.identifier.issue1en_US
dc.identifier.startpage187en_US
dc.identifier.trdizinid1244651en_US
dc.identifier.urihttps://doi.org/10.5455/medscience.2023.10.213
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1244651
dc.identifier.urihttps://hdl.handle.net/11616/89711
dc.identifier.volume13en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMedicine Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleLong-term effects of levetiracetam and valproic acid on laboratory parameters in childhood epilepsyen_US
dc.typeArticleen_US

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