A plasmonic biosensor pre-diagnostic tool for Familial Mediterranean Fever

Basit Öğe Kaydı
dc.contributor.authorKaraca Acari, Idil
dc.contributor.authorKurul, Fatma
dc.contributor.authorAvci, Meryem Beyza
dc.contributor.authorYasar, S. Deniz
dc.contributor.authorTopkaya, Seda Nur
dc.contributor.authorAcari, Ceyhun
dc.contributor.authorUnsal, Erbil
dc.date.accessioned2026-04-04T13:34:41Z
dc.date.available2026-04-04T13:34:41Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractFamilial Mediterranean Fever (FMF) is an autosomal recessive genetic disorder, primarily observed in populations around the Mediterranean Sea, linked to MEFV gene mutations. These mutations disrupt inflammatory responses, increasing pyrin-protein production. Traditional diagnosis relies on clinical symptoms, family history, acute phase reactants, and excluding similar syndromes with MEFV testing, which is expensive and often inconclusive due to heterozygous mutations. Here, we present a biosensor platform that detects differences in pyrin-protein levels between healthy and affected individuals, offering a cost-effective alternative to genetic testing. Our platform uses gold nanoparticle-based plasmonic chips enhanced with anti-pyrin antibodies, achieving a detection limit of 0.24 ng/mL with high specificity. The system integrates an optofluidic system and visible light spectroscopy for real-time analysis, with signal stability maintained for up to six months. Our technology will enhance FMF diagnosis accuracy, enabling early treatment initiation and providing a cost-effective alternative to genetic testing, thus improving patient care. There are currently no laboratory tests available for definitive diagnosis of Familial Mediterranean Fever (FMF). Here, the authors develop cost-effective and accurate plasmonic biosensor platform which detects pyrin-protein levels to aid diagnosis of FMF.
dc.description.sponsorshipThe Scientific and Technological Research Council of Turkiye (TUBITAK) through the 1005 - National New Ideas and New Products Research Funding Program [119E649]; EU [952346]
dc.description.sponsorshipA.E.C. acknowledges the support of The Scientific and Technological Research Council of Turkiye (TUBITAK) through the 1005 - National New Ideas and New Products Research Funding Program (Project No. 119E649). This study was also supported in part by the EU Horizon 2020 ERA Chairs Project RareBoost (Project No. 952346).
dc.identifier.doi10.1038/s41467-024-52961-8
dc.identifier.issn2041-1723
dc.identifier.issue1
dc.identifier.orcid0000-0002-7175-0015
dc.identifier.orcid0000-0002-0788-8108
dc.identifier.orcid0000-0001-6783-7030
dc.identifier.pmid39353949
dc.identifier.scopus2-s2.0-85205528702
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1038/s41467-024-52961-8
dc.identifier.urihttps://hdl.handle.net/11616/109345
dc.identifier.volume15
dc.identifier.wosWOS:001324215700004
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNature Portfolio
dc.relation.ispartofNature Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectProtein
dc.subjectSurface
dc.subjectPyrin
dc.subjectMefv
dc.subjectGene
dc.subjectMutations
dc.subjectDiagnosis
dc.subjectCriteria
dc.titleA plasmonic biosensor pre-diagnostic tool for Familial Mediterranean Fever
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu