P50 sensory gating in hypoxemic chronic obstructive pulmonary disease patients

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dc.authoridKamisli, Ozden/0000-0003-1114-7860
dc.authoridozcan, abdulcemal/0000-0002-6759-7556
dc.authoridKamisli, Suat/0000-0003-4281-3301
dc.authoridGulbas, Gazi/0000-0002-9435-8307
dc.authoridErmis, Hilal/0000-0002-1764-9098
dc.authoridKamisli, Ozden/0000-0003-1114-7860
dc.authorwosidKamisli, Suat/JVN-4663-2024
dc.authorwosidKamisli, Ozden/AAA-6553-2020
dc.authorwosidozcan, abdulcemal/B-1348-2008
dc.authorwosidKamisli, Suat/JZT-8388-2024
dc.authorwosidKamisli, Suat/AAC-2706-2021
dc.authorwosidGulbas, Gazi/ABI-5182-2020
dc.authorwosidErmis, Hilal/ABI-2900-2020
dc.contributor.authorKamisli, O.
dc.contributor.authorErmis, H.
dc.contributor.authorKamisli, S.
dc.contributor.authorGulbas, G.
dc.contributor.authorKablan, Y.
dc.contributor.authorOzcan, C.
dc.date.accessioned2024-08-04T20:37:37Z
dc.date.available2024-08-04T20:37:37Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPURPOSE: Chronic obstructive pulmonary disease (COPD) is a condition characterized by progressive airway obstruction and recurrent attacks. Multisystem involvement with extra-pulmonary manifestations has been seen in COPD patients. Numerous neurological involvement like cerebrovascular diseases, polyneuropathies, motor neuron diseases and cognitive impairement has been reported in COPD patients. Cognitive dysfunction is usually associated with hypoxia or hypercapnia in COPD patients. To our knowledge there is no study about sensory gating in COPD patients. We performed p50 test to COPD patients and we investigate sensory gating in COPD patients. PATIENTS AND METHODS: 25 male patients with COPD and 17 healthy male subjects for controls included to this study. The patients were diagnosed with COPD according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria. p50 amplitude and latency, percentage of P50 suppression, N100 amplitude and latency and the N100 suppression percentage of the COPD patients and controls presented were measured and compared. RESULTS: We found that the conditioning amplitudes (S1) did not differ between COPD patients and controls (p > 0.05) but (S2) amplitude was significantly increased in COPD patients (p < 0.05). COPD patients showed significantly lower P50 and N100 suppression percentage than controls (p < 0.05). CONCLUSIONS: COPD patients showed a disturbance cognitive function such as attention with p50 suppression rate decrease. P50 sensory gating test can be useful to analyze the pre-attention period of cognitive impairment in the early phase of COPD patients.en_US
dc.identifier.endpage200en_US
dc.identifier.issn1128-3602
dc.identifier.issue2en_US
dc.identifier.pmid23377807en_US
dc.identifier.scopus2-s2.0-84878558583en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage195en_US
dc.identifier.urihttps://hdl.handle.net/11616/96079
dc.identifier.volume17en_US
dc.identifier.wosWOS:000319224700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypoxemic chronic obstructive pulmonary diseaseen_US
dc.subjectchronic obstructive pulmonary diseaseen_US
dc.subjectCOPDen_US
dc.subjectSensory gating testen_US
dc.subjectp50 amplitude and latencyen_US
dc.titleP50 sensory gating in hypoxemic chronic obstructive pulmonary disease patientsen_US
dc.typeArticleen_US

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