The role of nitric oxide and cytokines in asthma-like syndrome induced by sulfur dioxide exposure in agricultural environment

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dc.authoridÇakır, Münire/0000-0001-8650-3722;
dc.authorwosidKoksal, Nurhan/AAA-3249-2022
dc.authorwosidÇakır, Münire/AAC-6583-2020
dc.authorwosidKöksal, Nurhan/AAG-5849-2021
dc.contributor.authorKoksal, N
dc.contributor.authorYildirim, Z
dc.contributor.authorGokirmak, M
dc.contributor.authorHasanoglu, HC
dc.contributor.authorMehmet, N
dc.contributor.authorAvci, H
dc.date.accessioned2024-08-04T20:13:28Z
dc.date.available2024-08-04T20:13:28Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: We previously demonstrated that apricot sulfurization workers are exposed to high concentrations of SO2, subsequently causing asthma-like syndrome. This study investigated the effects of SO, exposure on serum TNF-alpha, IL-1beta, IL-6, IL-8, nitrite and nitrate levels to understand the mechanism of SO-induced bronchoconstriction in asthma-like syndrome. Methods: We measured the serum levels of the cytokines, direct nitrite, total nitrite and nitrate obtained from 40 volunteer workers after an hour of exposure to SO2 and 23 healthy controls. Results: The concentrations of the cytokines, direct nitrite, total nitrite and nitrate were significantly (p < 0.0001) higher in the workers than in the controls. The mean serum concentrations of TNF-alpha, IL-1beta, IL-6, IL-8, direct nitrite, total nitrite and nitrate were 430.60 +/- 397.03 pg/ml, 436.67 +/- 316.31 pg/ml, 752.11 +/- 394,95 pg/ml, 262.12 +/- 287.99 pg/ml, 7.75 +/- 3.34 mumol/l, 115.72 +/- 48.78 mumol/l and 107.97 +/- 46.19 mumol/l in the workers, while they were 9.83 +/- 3.12 pg/ml, < 5 pg/ml, 7.49 +/- 1.27 pg/ml, 9.38 +/- 1.99 pg/ml, 2.17 +/- 0.77 mumol/l, 59.91 +/- 7.56 mumol/l and 57.74 +/- 7.20 mumol/l in the controls, respectively. Conclusion: These results show that TNF-alpha, IL-1beta, IL-6, IL-8 and nitric oxide may play a role in the pathogenesis of bronchoconstriction in asthma-like syndrome due to the SO2 exposure. (C) 2003 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/S0009-8981(03)00334-6
dc.identifier.endpage122en_US
dc.identifier.issn0009-8981
dc.identifier.issn1873-3492
dc.identifier.issue1-2en_US
dc.identifier.pmid14500043en_US
dc.identifier.scopus2-s2.0-0142185030en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage115en_US
dc.identifier.urihttps://doi.org/10.1016/S0009-8981(03)00334-6
dc.identifier.urihttps://hdl.handle.net/11616/93641
dc.identifier.volume336en_US
dc.identifier.wosWOS:000185809400016en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofClinica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsulfur dioxideen_US
dc.subjectbronchoconstrictionen_US
dc.subjectcytokinesen_US
dc.subjectnitric oxideen_US
dc.titleThe role of nitric oxide and cytokines in asthma-like syndrome induced by sulfur dioxide exposure in agricultural environmenten_US
dc.typeArticleen_US

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