Outcome of COVID-19 in Patients With Autoimmune Hepatitis: An International Multicenter Study

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dc.authoridEren, Fatih/0000-0003-2667-8963
dc.authoridEbik, Berat/0000-0002-0012-2505
dc.authoridRidruejo, Ezequiel/0000-0002-3321-0683
dc.authoridCristoferi, Laura/0000-0001-9846-7474
dc.authoridDrenth, Joost/0000-0001-8027-3073
dc.authoridTorgutalp, Murat/0000-0003-4600-9484
dc.authoridGómez Aldana, Andres/0000-0002-7954-4910
dc.authorwosidEren, Fatih/JQJ-3328-2023
dc.authorwosidEbik, Berat/AAM-5646-2020
dc.authorwosidRidruejo, Ezequiel/H-7965-2019
dc.authorwosidCristoferi, Laura/ABA-7458-2022
dc.authorwosidDrenth, Joost/V-7436-2019
dc.authorwosidTorgutalp, Murat/ABA-3372-2021
dc.authorwosidGómez Aldana, Andres/JDD-2216-2023
dc.contributor.authorEfe, Cumali
dc.contributor.authorDhanasekaran, Renumathy
dc.contributor.authorLammert, Craig
dc.contributor.authorEbik, Berat
dc.contributor.authorHiguera-de la Tijera, Fatima
dc.contributor.authorAloman, Costica
dc.contributor.authorCaliskan, Ali Riza
dc.date.accessioned2024-08-04T20:50:19Z
dc.date.available2024-08-04T20:50:19Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Aims Data regarding outcome of COVID-19 in patients with autoimmune hepatitis (AIH) are lacking. Approach and Results We performed a retrospective study on patients with AIH and COVID-19 from 34 centers in Europe and the Americas. We analyzed factors associated with severe COVID-19 outcomes, defined as the need for mechanical ventilation, intensive care admission, and/or death. The outcomes of patients with AIH were compared to a propensity score-matched cohort of patients without AIH but with chronic liver diseases (CLD) and COVID-19. The frequency and clinical significance of new-onset liver injury (alanine aminotransferase > 2 x the upper limit of normal) during COVID-19 was also evaluated. We included 110 patients with AIH (80% female) with a median age of 49 (range, 18-85) years at COVID-19 diagnosis. New-onset liver injury was observed in 37.1% (33/89) of the patients. Use of antivirals was associated with liver injury (P = 0.041; OR, 3.36; 95% CI, 1.05-10.78), while continued immunosuppression during COVID-19 was associated with a lower rate of liver injury (P = 0.009; OR, 0.26; 95% CI, 0.09-0.71). The rates of severe COVID-19 (15.5% versus 20.2%, P = 0.231) and all-cause mortality (10% versus 11.5%, P = 0.852) were not different between AIH and non-AIH CLD. Cirrhosis was an independent predictor of severe COVID-19 in patients with AIH (P < 0.001; OR, 17.46; 95% CI, 4.22-72.13). Continuation of immunosuppression or presence of liver injury during COVID-19 was not associated with severe COVID-19. Conclusions This international, multicenter study reveals that patients with AIH were not at risk for worse outcomes with COVID-19 than other causes of CLD. Cirrhosis was the strongest predictor for severe COVID-19 in patients with AIH. Maintenance of immunosuppression during COVID-19 was not associated with increased risk for severe COVID-19 but did lower the risk for new-onset liver injury during COVID-19.en_US
dc.description.sponsorshipNational Institute on Alcohol Abuse and Alcoholism [R01AA024762] Funding Source: NIH RePORTERen_US
dc.identifier.doi10.1002/hep.31797
dc.identifier.endpage2109en_US
dc.identifier.issn0270-9139
dc.identifier.issn1527-3350
dc.identifier.issue6en_US
dc.identifier.pmid33713486en_US
dc.identifier.scopus2-s2.0-85108083780en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2099en_US
dc.identifier.urihttps://doi.org/10.1002/hep.31797
dc.identifier.urihttps://hdl.handle.net/11616/99991
dc.identifier.volume73en_US
dc.identifier.wosWOS:000663150100004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofHepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDeterminantsen_US
dc.titleOutcome of COVID-19 in Patients With Autoimmune Hepatitis: An International Multicenter Studyen_US
dc.typeArticleen_US

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