Immunhistochemical analysis of Nuclear Factor Kappa Beta expression in etiopathogenesis of ovarian tumors

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dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authorwosidköleli, ışıl/ABI-7318-2020
dc.authorwosidMELEKOGLU, RAUF/AAF-1614-2019
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorGul, Mehmet
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorKoleli, Isil
dc.date.accessioned2024-08-04T20:45:22Z
dc.date.available2024-08-04T20:45:22Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: To investigate the place of the transcription factor nuclear kappa B (NF-kappa B), which is a marker of chronic inflammation, in the etiology of the ovarian carcinoma. Methods: NFkB analysis with the immunohistochemical method has been performed. To evaluate immunohistochemical NF-kappa B expression in the ovarian tissue, the H-score method. H-score = Sigma Pi (i+1), where Pi'' is the percentage of stained cells in each intensity category (0-100%) and i'' is the intensity indicating weak (i=1), moderate (i=2) or strong staining (i=3). Results: It has been seen that, the mean H score is statistically significantly higher in the patient group with serous and musinous adenocarcinoma diagnosis than the two other patient groups (p<0.005). Conclusions: Factor nuclear kappa B is an important mediator that acts in the chronic inflammation. The highest expression rates are determined by the immunohistochemical method in the ovarian cancer group.en_US
dc.identifier.doi10.1590/s0102-865020180070000009
dc.identifier.endpage650en_US
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue7en_US
dc.identifier.pmid30110065en_US
dc.identifier.scopus2-s2.0-85051722790en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage641en_US
dc.identifier.urihttps://doi.org/10.1590/s0102-865020180070000009
dc.identifier.urihttps://hdl.handle.net/11616/98433
dc.identifier.volume33en_US
dc.identifier.wosWOS:000441179000009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNF-kappa Ben_US
dc.subjectOvarianen_US
dc.subjectNeoplasmsen_US
dc.subjectInflammationen_US
dc.subjectEtiologyen_US
dc.titleImmunhistochemical analysis of Nuclear Factor Kappa Beta expression in etiopathogenesis of ovarian tumorsen_US
dc.typeArticleen_US

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