New compounds based on a benzimidazole nucleus: synthesis, characterization and cytotoxic activity against breast and colon cancer cell lines

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dc.authoridKayser, Veysel/0000-0003-1310-9534
dc.authoridAkkoc, Senem/0000-0002-1260-9425
dc.authoridHawkins, Bryson/0000-0002-0280-039X
dc.authoridLai, Felcia/0000-0002-5051-4830
dc.authorwosidAkkoç, Senem/AAN-1478-2021
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidKayser, Veysel/HKN-5249-2023
dc.authorwosidİLHAN, İLHAN ÖZER/AAN-1469-2021
dc.authorwosidWilliams, Philip A/F-5935-2015
dc.contributor.authorAkkoc, Senem
dc.contributor.authorKayser, Veysel
dc.contributor.authorIlhan, Ilhan Ozer
dc.contributor.authorHibbs, David E.
dc.contributor.authorGok, Yetkin
dc.contributor.authorWilliams, Peter A.
dc.contributor.authorHawkins, Bryson
dc.date.accessioned2024-08-04T20:43:05Z
dc.date.available2024-08-04T20:43:05Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBenzimidazolium salts and their Pyridine Enhanced Precatalyst Preparation Stabilization and Initiation (PEPPSI) palladium N-heterocyclic carbene (Pd-NHC) based complexes have been synthesized and their structures characterized with a number of different instrumental techniques including NMR (H-1 and C-13), IR, EI-MS (for 2), X-ray (for 1, 2 and 4) and elemental analysis. The cytotoxicity of all the compounds was tested using the human embryonic kidney (HEK-293T), human breast epithelial adenocarcinoma (MDA-MB-231), and human colon epithelial colorectal adenocarcinoma (DLD-1) cell lines. The benzimidazolium salts (2-5) had more cytotoxic activity against cancerous cells compared with the metal complexes (6-9), which curiously exhibited no activity against any of the cell lines. Based on the IC50 values, compound 5 displayed the highest in vitro anticancer activity among compounds 2-9. Crown Copyright (C) 2017 Published by Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipTUBITAK, Turkey [1059B141400496]; Erciyes University Research Fund [FDK-2014-5091]; Faculty of Pharmacy, The University of Sydneyen_US
dc.description.sponsorshipThis study was financially supported by TUBITAK, Turkey (1059B141400496), Erciyes University Research Fund (FDK-2014-5091) and the Faculty of Pharmacy, The University of Sydney. We would also like to thank Associate Professor Brian Hawkett, Dr Binh Pham and Dr Byung Kim of The Key Centre for Polymers and Colloids, The University of Sydney, for donating the DLD-1 cells and useful discussions, and Kathy On for her help in conducting the in vitro cell culture experiments. We thank Dr Nial Wheate (The University of Sydney) for his critical reading of the manuscript.en_US
dc.identifier.doi10.1016/j.jorganchem.2017.03.037
dc.identifier.endpage107en_US
dc.identifier.issn0022-328X
dc.identifier.issn1872-8561
dc.identifier.scopus2-s2.0-85017569714en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage98en_US
dc.identifier.urihttps://doi.org/10.1016/j.jorganchem.2017.03.037
dc.identifier.urihttps://hdl.handle.net/11616/97783
dc.identifier.volume839en_US
dc.identifier.wosWOS:000401126300014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal of Organometallic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Heterocyclic carbeneen_US
dc.subjectPEPPSIen_US
dc.subjectBenzimidazolium saltsen_US
dc.subjectCytotoxic activityen_US
dc.subjectX-rayen_US
dc.subjectConfocal and incucyte imagesen_US
dc.titleNew compounds based on a benzimidazole nucleus: synthesis, characterization and cytotoxic activity against breast and colon cancer cell linesen_US
dc.typeArticleen_US

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