Central irisin administration suppresses thyroid hormone production but increases energy consumption in rats

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dc.authoridÖzyalın, Fatma/0000-0001-6486-6389
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authoridözyalın, fatma/0000-0001-6486-6389
dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridErden, Yavuz/0000-0002-2807-6096
dc.authorwosidÖzyalın, Fatma/ABC-7193-2020
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidCigremis, Yilmaz/O-6019-2015
dc.authorwosidErden, Yavuz/IZE-2291-2023
dc.authorwosidözyalın, fatma/ABA-5258-2020
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.authorwosidCigremis, Yilmaz/JAC-8451-2023
dc.contributor.authorTekin, Suat
dc.contributor.authorErden, Yavuz
dc.contributor.authorOzyalin, Fatma
dc.contributor.authorOnalan, Ebru Etem
dc.contributor.authorCigremis, Yilmaz
dc.contributor.authorColak, Cemil
dc.contributor.authorTekedereli, Ibrahim
dc.date.accessioned2024-08-04T20:44:24Z
dc.date.available2024-08-04T20:44:24Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIrisin, which is secreted from the skeletal muscle in response to physical exercise and defined as a thermogenic peptide, may play an important role in energy metabolism. Thyroid hormones, which are one of the other influential factors on the metabolic status, increase heat production and are the main regulators of energy metabolism. This study was conducted to determine the possible effects of irisin administration on thyroid hormones. Forty adult male Wistar albino rats were used in the study. The rats were equally divided into 4 groups (n = 10). The brain infusion kit was implanted in the groups, and irisin (or solvent as control) was centrally administered to the rats via osmotic mini pumps for 7 days. During the experiment, food consumption, body weights, and body temperatures of the animals were recorded. Food intake was significantly increased in the groups treated with irisin (p < 0.05), but their body weights were not changed. Hypothalamic TRH gene expression, serum TSH, fT3, and fT4 levels were significantly lower in the groups treated with irisin as compared to the naive and control groups (p < 0.05). In addition, irisin increased UCP1 mRNA expression in white and brown adipose tissue and UCP3 mRNA expression in muscle tissue in rats and also raised their body temperature (p < 0.05). Consequently, although central irisin administration has inhibitory effects on the hypothalamic-pituitary thyroid axis, it seems to be an important agent in the regulation of food intake and energy metabolism.en_US
dc.description.sponsorshipScientific & Technological Research Council of Turkey (TUBITAK) [214S640]en_US
dc.description.sponsorshipThis study was supported by The Scientific & Technological Research Council of Turkey (TUBITAK; Project no: 214S640).en_US
dc.identifier.doi10.1016/j.neulet.2018.03.046
dc.identifier.endpage141en_US
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.pmid29574218en_US
dc.identifier.scopus2-s2.0-85044470507en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage136en_US
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2018.03.046
dc.identifier.urihttps://hdl.handle.net/11616/98211
dc.identifier.volume674en_US
dc.identifier.wosWOS:000430889200024en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIrisinen_US
dc.subjectHPT axisen_US
dc.subjectThyroid hormonesen_US
dc.subjectEnergy metabolismen_US
dc.subjectUncoupling proteinsen_US
dc.titleCentral irisin administration suppresses thyroid hormone production but increases energy consumption in ratsen_US
dc.typeArticleen_US

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