Miniaturized lensless imaging systems for cell and microorganism visualization in point-of-care testing

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dc.authoridGeckil, Hikmet/0000-0003-0070-0691
dc.authoridGurkan, Umut A./0000-0002-0331-9960
dc.authoridXu, Feng/0000-0003-4351-0222
dc.authorwosidXu, Feng/C-7430-2011
dc.authorwosidLu, Tian Jian/E-6063-2016
dc.authorwosidGeckil, Hikmet/F-7647-2012
dc.authorwosidWang, Shuqi/F-2861-2011
dc.authorwosidGurkan, Umut A./Z-2496-2019
dc.authorwosidlu, tairong/IUO-6758-2023
dc.authorwosidXu, Feng/H-4468-2011
dc.contributor.authorGurkan, Umut Atakan
dc.contributor.authorMoon, Sangjun
dc.contributor.authorGeckil, Hikmet
dc.contributor.authorXu, Feng
dc.contributor.authorWang, Shuqi
dc.contributor.authorLu, Tian Jian
dc.contributor.authorDemirci, Utkan
dc.date.accessioned2024-08-04T20:32:42Z
dc.date.available2024-08-04T20:32:42Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractLow-cost, robust, and user-friendly diagnostic capabilities at the point-of-care (POC) are critical for treating infectious diseases and preventing their spread in developing countries. Recent advances in micro- and nanoscale technologies have enabled the merger of optical and fluidic technologies (optofluidics) paving the way for cost-effective lensless imaging and diagnosis for POC testing in resource-limited settings. Applications of the emerging lensless imaging technologies include detecting and counting cells of interest, which allows rapid and affordable diagnostic decisions. This review presents the advances in lensless imaging and diagnostic systems, and their potential clinical applications in developing countries. The emerging technologies are reviewed from a POC perspective considering cost effectiveness, portability, sensitivity, throughput and ease of use for resource-limited settings.en_US
dc.description.sponsorshipUS Department of the Defense (DOD); Coulter Foundation; NIH [R01AI081534, R21AI087107]; Center for Integration of Medicine and Innovative Technology (CIMIT) under U.S. Army Medical Research Acquisition Activity Cooperative Agreement; National Natural Science Foundation [30150110125]; U.S. Army Medical Research & Material Command (USAMRMC); Telemedicine & Advanced Technology Research Center (TATRC), at Fort Detrick, MDen_US
dc.description.sponsorshipThis work was performed at the Demirci Bio-Acoustic MEMS in Medicine (BAMM) Labs at the HST-BWH Center for Bioengineering, Harvard Medical School. This work was partially supported by New Development Grant of the US Department of the Defense (DOD). We would like to acknowledge the Coulter Foundation Young Investigator Award, NIH (R01AI081534), NIH (R21AI087107), the Center for Integration of Medicine and Innovative Technology (CIMIT) under U.S. Army Medical Research Acquisition Activity Cooperative Agreement..; Dr. Demirci thanks the The China Research Fund for International Young Scientists (30150110125) through the National Natural Science Foundation Young Scholars Research Fund. This study was made possible by a research grant that was awarded and administered by the U.S. Army Medical Research & Material Command (USAMRMC) and the Telemedicine & Advanced Technology Research Center (TATRC), at Fort Detrick, MD.en_US
dc.identifier.doi10.1002/biot.201000427
dc.identifier.endpage149en_US
dc.identifier.issn1860-6768
dc.identifier.issn1860-7314
dc.identifier.issue2en_US
dc.identifier.pmid21298800en_US
dc.identifier.scopus2-s2.0-79551618564en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage138en_US
dc.identifier.urihttps://doi.org/10.1002/biot.201000427
dc.identifier.urihttps://hdl.handle.net/11616/95248
dc.identifier.volume6en_US
dc.identifier.wosWOS:000287718500002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofBiotechnology Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLensless imagingen_US
dc.subjectMicrofluidicsen_US
dc.subjectPoint-of-careen_US
dc.subjectResource-limited settingsen_US
dc.titleMiniaturized lensless imaging systems for cell and microorganism visualization in point-of-care testingen_US
dc.typeReview Articleen_US

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