Is edema in minimal change disease of childhood really hypovolemic?

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dc.authoridKARAKURT, CEMŞIT/0000-0002-9246-8107
dc.authorwosidAKIN, Ilke Mungan/ABE-7061-2020
dc.authorwosidTabel, Yilmaz/AAF-9801-2020
dc.authorwosidKARAKURT, CEMŞIT/ABE-2330-2020
dc.contributor.authorTabel, Yilmaz
dc.contributor.authorMungan, Ilke
dc.contributor.authorKarakurt, Cemsit
dc.contributor.authorKocak, Gulendam
dc.contributor.authorGungor, Serdal
dc.date.accessioned2024-08-04T20:30:56Z
dc.date.available2024-08-04T20:30:56Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives In this study, we aimed to find out whether children with minimal change disease can be classified as hypervolemic by objective measures. Methods Eighteen children with minimal change disease diagnosed at our department between November 2005 and May 2007 were included in this study. All patients were newly diagnosed or relapsed but were steroid free for at least 6 months. In the first week of edema and when edema resolved (5-7 days after initiation of therapy), weight, height and blood pressure were obtained from all patients. Serum and plasma samples were taken following a starvation period of 12-14 h. The volume load of all patients was evaluated, measuring the inferior vena cava indices in each stage by echocardiography. Results Average weight at presentation was 8.5% higher than the ideal (dry) weight. There were significant differences between the first and post-treatment body weights, abdomen circumference, and systolic and diastolic blood pressure values (P < 0.05 for each). The inferior vena cava index (IVCI) values decreased significantly after diuretic treatment (P < 0.001), while inferior vena cava collapsibility index (IVCCI) values increased in the post-treatment period (P < 0.001). Conclusion We believe that a close follow-up of hypervolemic children with MCD, treated solely with easy-to-handle diuretics instead of I.V. albumin and diuretics may properly solve the edematous state in these patients.en_US
dc.identifier.doi10.1007/s11255-008-9344-9
dc.identifier.endpage761en_US
dc.identifier.issn0301-1623
dc.identifier.issue3en_US
dc.identifier.pmid18415025en_US
dc.identifier.scopus2-s2.0-48549085927en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage757en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-008-9344-9
dc.identifier.urihttps://hdl.handle.net/11616/94609
dc.identifier.volume40en_US
dc.identifier.wosWOS:000258063200033en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Urology and Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchildhooden_US
dc.subjectdiureticen_US
dc.subjectedemaen_US
dc.subjectminimal change diseaseen_US
dc.subjectnephrotic syndromeen_US
dc.titleIs edema in minimal change disease of childhood really hypovolemic?en_US
dc.typeArticleen_US

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