Melatonin preserves ovarian tissues of rats exposed to chronic TCDD: An electron microscopic approach to effects of TCDD on ovarian cells
Yükleniyor...
Dosyalar
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
SAGE PUBLICATIONS INC, 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a toxic agent and has disruptive effects on reproductive tissues in females. TCDD disrupts the hormonal regulation of the body and decreases the production of melatonin. In this study, we investigated the protective effects of melatonin supplements against the toxic effects of TCDD on ovaries of female rats. TCDD caused a significant decrease in the average number of corpora lutea and follicles per tissue section (2.1 +/- 0.7; 2.3 +/- 0.8, respectively), whereas these numbers were maintained in the melatonin supplemented group (5.0 +/- 0.8; 5.1 +/- 0.8, respectively) and were similar to the control group (5.3 +/- 1.0; 5.9 +/- 0.9, respectively). Electron microscopic analysis showed that the disruption of ultrastructure components such as cell membrane and organelles due to TCDD exposure was inhibited by melatonin supplements. This study suggested that melatonin has a protective and a possible ameliorative effect over histopathological damage of rat ovaries exposed to TCDD.
Açıklama
Anahtar Kelimeler
2,3,7,8-Tetrachlorodıbenzo-P-Dıoxın Tcdd, Endocrıne Dısruptors, Pharmacokınetıcs, Mechanısm, Cancer, Dıoxın
Kaynak
Toxıcology and ındustrıal health
WoS Q Değeri
Scopus Q Değeri
Cilt
34
Sayı
4
Künye
Gül, S. Gül, M. Yiğitcan, M. (2018). Melatonin preserves ovarian tissues of rats exposed to chronic TCDD: An electron microscopic approach to effects of TCDD on ovarian cells. Cilt:34 Sayı:4, 228-236 ss.
